1,2-Bis(chloromethoxy)ethane

Base Information

• Chemical Name: 1,2-Bis(chloromethoxy)ethane
• CAS No.: 13483-18-6
• Molecular Formula: C4H8 Cl2 O2
• Molecular Weight: 159.012
• Hs Code.: 2909199090
• European Community (EC) Number: 236-791-6
• NSC Number: 508881
• UNII: 64W2G7H6SA
• DSSTox Substance ID: DTXSID3020170
• Nikkaji Number: J34.807D
• Wikidata: Q27155925
• Mol file: 13483-18-6.mol

Synonyms:1,2-bis(chloromethoxy)ethane

Chemical Property of 1,2-Bis(chloromethoxy)ethane

Chemical Property:

• Vapor Pressure: 0.89mmHg at 25°C
• Refractive Index: 1.4386 (estimate)
• Boiling Point: 186.9°Cat760mmHg
• Flash Point: 71.6°C
• PSA: 18.46000
• Density: 1.222g/cm³
• LogP: 1.41220
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: Chloroform (Slightly), Dichloromethane (Slightly), Methanaol (Slightly)
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 157.9901349
• Heavy Atom Count: 8
• Complexity: 37

Purity/Quality:

99% ^*data from raw suppliers

1,2-BIS(CHLOROMETHOXY)ETHANE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Questionable carcinogen.
• Hazard Codes: Questionable carcinogen.

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Other Classes -> Other Organic Compounds
• Canonical SMILES: C(COCCl)OCCl
• Uses: 1,2-bis(Chloromethoxy)ethane is a carcinogenic compound.

Technology Process of 1,2-Bis(chloromethoxy)ethane

There total 6 articles about 1,2-Bis(chloromethoxy)ethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + ethylene glycol (107-21-1) → 1,2-bis(chloromethoxy)ethane (13483-18-6)

Guidance literature:

With hydrogenchloride; at 20 ℃; for 2h;

DOI:10.3390/molecules17088735

Reference yield:

ethylene glycol (107-21-1) → 1,2-bis(chloromethoxy)ethane (13483-18-6)

Guidance literature:

With paraformaldehyde;

Reference yield:

boric acid tris-(2-chloromethoxy-ethyl) ester (93228-13-8) → 1,2-bis(chloromethoxy)ethane (13483-18-6) + 2-(2-chloromethoxy-ethoxy)-[1,3,2]dioxaborolane (90800-85-4)

Guidance literature:

at 56 ℃; under 0.3 Torr;

upstream raw materials:

formaldehyd

ethylene glycol

boric acid tris-(2-chloromethoxy-ethyl) ester

1,3,5-Trioxan

Downstream raw materials:

1,2-bis-methoxymethoxy-ethane

di-n-butyloxymethane

1,2-bis-butoxymethoxy-ethane

bis-(2-butoxymethoxy-ethyl) ether

Refernces

• 1、 Pa?kowski, ?ukasz,B?aszczyński, Jerzy,Skrzypczak, Andrzej,B?aszczak, Jan,Kozakowska, Karolina,Wróblewska, Joanna,Kozuszko, Sylwia,Gospodarek, Eugenia,Krysiński, Jerzy,S?owiński, Roman. "Antimicrobial activity and SAR study of new gemini imidazolium-based chlorides". . p. 278 - 288. Retrieved 2014.
• 2、 Ross,S.D. et al.. "-". . p. 2193 - 2198. Retrieved 1973.
• 3、 Dong, Min,Si, Yuan-Qi,Sun, Shuang-Yong,Pu, Xiao-Ping,Yang, Zhen-Jun,Zhang, Liang-Ren,Zhang, Li-He,Leung, Fung Ping,Lam, Connie Mo Ching.,Kwong, Anna Ka Yee,Yue, Jianbo,Zhou, Yeyun,Kriksunov, Irina A.,Hao, Quan,Cheung Lee, Hon. "Design, synthesis and biological characterization of novel inhibitors of CD38". scheme or table. p. 3246 - 3257. Retrieved 2011/06/10.