2-Amino-3-methylpyridine

Base Information

• Chemical Name: 2-Amino-3-methylpyridine
• CAS No.: 1603-40-3
• Molecular Formula: C6H8N2
• Molecular Weight: 108.143
• Hs Code.: 29333999
• European Community (EC) Number: 216-501-4
• NSC Number: 450
• UNII: Y2WWD85QY6
• DSSTox Substance ID: DTXSID3051759
• Nikkaji Number: J21.555D
• Wikipedia: 2-amino-3-methylpyridine
• Wikidata: Q27294187
• Pharos Ligand ID: TGM4A2CYUNB8
• ChEMBL ID: CHEMBL291544
• Mol file: 1603-40-3.mol

Synonyms:2-amino-3-methylpyridine;2A3MP cpd

Chemical Property of 2-Amino-3-methylpyridine

Chemical Property:

• Appearance/Colour: clear yellow liquid after melting
• Vapor Pressure: 0.11mmHg at 25°C
• Melting Point: 29-31 °C(lit.)
• Refractive Index: n20/D 1.5823(lit.)
• Boiling Point: 220.9 °C at 760 mmHg
• PKA: pK1: 7.24(+1) (25°C)
• Flash Point: 109.9 °C
• PSA: 38.91000
• Density: 1.068 g/cm³
• LogP: 1.55340
• Storage Temp.: Store below +30°C.
• Sensitive.: Hygroscopic
• Solubility.: 1000g/l
• Water Solubility.: SOLUBLE
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 108.068748264
• Heavy Atom Count: 8
• Complexity: 72.9

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-3-methylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 23/24/25-33-36/37/38-25
• Safety Statements: 36/37/39-45-37/39-28A-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1=C(N=CC=C1)N
• Uses: 2-Amino-3-picoline is used in the synthesis of ketones from aldehydes.

Technology Process of 2-Amino-3-methylpyridine

There total 20 articles about 2-Amino-3-methylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-bromo-3-picoline (3430-17-9) → 3-methylpyridin-2-ylamine (1603-40-3)

Guidance literature:

With copper(I) oxide; potassium carbonate; ammonium hydroxide; N,N-dimethylethylenediamine; In ethylene glycol; at 60 ℃; for 16h; Inert atmosphere;

DOI:10.1039/b916569j

Reference yield: 96.0%

N-Cyclohexyl-8-methyl-2-phenylimidazo[1,2-a]pyridin-3-amine → 3-methylpyridin-2-ylamine (1603-40-3) + N-cicloesil-α-ossofenilacetamide (724-92-5)

Guidance literature:

With [bis(acetoxy)iodo]benzene; toluene-4-sulfonic acid; In 1,2-dichloro-ethane; at 20 ℃; for 1h; chemoselective reaction; Schlenk technique;

DOI:10.1021/acs.joc.9b00208

Reference yield: 96.0%

→ 3-methylpyridin-2-ylamine (1603-40-3)

Guidance literature:

upstream raw materials:

3-Methylpyridine

tetrachloromethane

3-picoline-N-oxide

2 chloro-3-methylpyridine

Downstream raw materials:

7-(((3-methylpyridin-2-yl)amino)(phenyl)methyl)quinolin-8-ol

(3-methyl-[2]pyridyl)-picryl-amine

N-(2-pyridyl-3-methyl)acetamide

N-(3-methyl-[2]pyridyl)-dibenzamide

Refernces

• 1、 Yuan, Xiong-Jun,Xue, Wei-Lan,Zeng, Zuo-Xiang,Pu, Tong. "Vapor pressure and enthalpy of vaporization of 2-amino-3-methylpyridine". . p. 2431 - 2435. Retrieved 2007.
• 2、 Ronson, Thomas O.,Renders, Evelien,Van Steijvoort, Ben F.,Wang, Xubin,Wybon, Clarence C. D.,Prokopcová, Hana,Meerpoel, Lieven,Maes, Bert U. W.. "Ruthenium-Catalyzed Reductive Arylation of N-(2-Pyridinyl)amides with Isopropanol and Arylboronate Esters". supporting information. p. 482 - 487. Retrieved 2019/01/04.
• 3、 -. "New synthesis method of 2-amino-3-methylpyridine". Page/Page column 3-4. . Retrieved 2019/05/15.