2-(2-Bromoethoxy)tetrahydro-2H-pyran

Base Information

• Chemical Name: 2-(2-Bromoethoxy)tetrahydro-2H-pyran
• CAS No.: 17739-45-6
• Deprecated CAS: 59146-56-4,1603834-15-6
• Molecular Formula: C₇H₁₃BrO₂
• Molecular Weight: 209.083
• Hs Code.: 29329900
• European Community (EC) Number: 827-879-0
• NSC Number: 216078
• DSSTox Substance ID: DTXSID20884985
• Nikkaji Number: J421.998H
• Mol file: 17739-45-6.mol

Synonyms:2-(2-Bromoethoxy)tetrahydro-2H-pyran;17739-45-6;2-(2-bromoethoxy)oxane;59146-56-4;2H-Pyran, 2-(2-bromoethoxy)tetrahydro-;172797-67-0;2-(2-bromoethoxy)tetrahydropyran;2-(2-bromoethoxy)-tetrahydro-2H-pyran;2h-pyran,3-(2-bromoethoxy)tetrahydro-;MFCD01321310;2-[(2-Bromoethyl)oxy]tetrahaydro-2H-pyran;2(2-bromoethoxy)tetrahydro-2h-pyran;NSC 216078;2-((2-Bromoethyl)oxy)tetrahaydro-2H-pyran;2-(2-Bromo-ethoxy)-tetrahydro-pyran;2H-Pyran, 2-(2-bromoethoxy)tetrahydro-, (A+/-)-;2-(2-Bromoethoxy) tetrahydro-2H-pyran;NSC216078;O(CCBr)C1CCCCO1;2-bromoethyl tetrahydro-2H-pyran-2-yl ether;2-bromoethoxytetrahydropyran;SCHEMBL57544;2-(2-bromoethoxy)terahydropyran;DTXSID20884985;2-(2-bromoethyoxy)tetrahydropyran;2-(2'-bromoethoxy)tetrahydropyran;2-(2-bromo-ethoxy)tetrahydropyran;2-(2-bromoethoxy) tetrahydropyran;2-(2-bromoethoxy)-tetrahydropyran;2-(2-Bromoethoxyl)tetrahydropyran;2-tetrahydropyranyloxyethyl bromide;2-(2-bromoethyl)oxytetrahydropyran;2-(2-bromoethyloxy)tetrahydropyran;(2-bromoethoxy)tetrahydro-2H-pyran;AMY24778;1-bromo-2-tetrahydropyranyloxyethane;2-(2-bromo-ethoxy)-tetrahydropyran;2-(2-bromoethoxy)-tetra-hydropyran;2-bromo-1-tetrahydropyranyloxyethane;2-tetrahydropyranyloxy-1-bromoethane;2-bromoethyltetrahydro-2-pyranylether;BBL102426;STL556228;1-bromo-2-tetrahydropyranyloxy-ethane;2-(2-bromoethoxy)tetrahydro-2h pyran;2-(2-bromoethoxy)tetrahydro-2H-piran;AKOS005216100;AKOS016843464;2-(2-bromethoxy)tetrahydro-2-H-pyran;2-(2-bromoethoxy)tetrahydro-2H-pyrane;2-Tetrahydropyran-2-yloxyethyl bromide;CS-W015177;NSC-216078;2-(2-bromoethoxy)tetrahydro-2 h-pyran;2-(2-Bromoethoxyl)tetrahydro-2H-pyran;2-(2-tetrahydropyranyloxy)ethyl bromide;2-bromoethyl 2-tetrahydro-pyranyl ether;2-bromoethyl tetrahydropyran-2-yl ether;2H-Pyran,2-(2-bromoethoxy)tetrahydro-;tetrahydro-2-(2-bromoethoxy)-2H-pyran;tetrahydro-2-pyranyl 2-bromoethyl ether;1-bromo-2-tetrahydropyran-2-yloxyethane;2-(2-bromoethoxy)-tetrahydro-2H-pyrane;1-bromo-2-(2-tetrahydropyranyloxy)ethane;2-(tetrahydropyran-2-yl)oxyethyl bromide;2-bromo-1-(2-tetrahydropyranyloxy)ethane;2-bromoethyl- tetrahydropyran-2-yl ether;AC-25469;DS-12519;SY038937;2-[(2-bromoethyl)oxy]tetrahydro-2H-pyran;1-(tetrahydropyran-2-yloxy)-2-bromoethane;1-bromo-2-(tetrahydro-2-pyranyloxy)ethane;1-bromo-2-(tetrahydropyran-2-yloxy)ethane;2-[(tetrahydropyran-2-yl)oxy]ethyl bromide;1-bromo-2-(2- tetrahydropyranyloxy) ethane;1-bromo-2-(tetrahydropyran-2-yloxy) ethane;A3935;B2850;FT-0650123;FT-0730586;FT-0767882;2-(2-Bromoethoxy)tetrahydro-2H-pyran, 96%;2-[(tetrahydropyran-2-yl)oxy] ethyl bromide;EN300-54203;F30079;A832181;J-505549

Chemical Property of 2-(2-Bromoethoxy)tetrahydro-2H-pyran

Chemical Property:

• Appearance/Colour: Clear pale yellow liquid
• Refractive Index: n20/D 1.482(lit.)
• Boiling Point: 257.8 °C at 760 mmHg
• Flash Point: 112.5 °C
• PSA: 18.46000
• Density: 1.371 g/cm³
• LogP: 1.92450
• Storage Temp.: 0-10°C
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 208.00989
• Heavy Atom Count: 10
• Complexity: 87.7

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(2-Bromoethoxy)tetrahydro-2H-pyran ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CCOC(C1)OCCBr
• Uses: 2-(2-Bromoethoxy)tetrahydro-2H-pyran may be used in the synthesis of:4-(2-chloroethoxy)benzenesulfonyl chloride estrogen ligands bearing carborane2-(2-(1,3-di((E)-2-(2-(2-(2-(5-(4-(tert-butoxycarbonyl(methyl)amino)styryl)pyridin-2-yloxy)ethoxy)ethoxy)ethoxy)ethoxy)propan-2-yloxy)ethoxy)-tetrahydro-2H-pyran

Technology Process of 2-(2-Bromoethoxy)tetrahydro-2H-pyran

There total 9 articles about 2-(2-Bromoethoxy)tetrahydro-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3,4-dihydro-2H-pyran (110-87-2) + 2-bromoethanol (540-51-2) → 2-(2-bromoethoxy)tetrahydropyran (17739-45-6,59146-56-4)

Guidance literature:

With pyridinium p-toluenesulfonate; In dichloromethane;

DOI:10.1135/cccc20041843

Reference yield: 80.0%

TETRAHYDROPYRANE (142-68-7) + 2-bromoethanol (540-51-2) → 2-(2-bromoethoxy)tetrahydropyran (17739-45-6,59146-56-4)

Guidance literature:

With toluene-4-sulfonic acid; at 20 ℃;

Reference yield: 70.0%

2-bromoethanol (540-51-2) → 2-(2-bromoethoxy)tetrahydropyran (17739-45-6,59146-56-4)

Guidance literature:

2-bromoethanol; With toluene-4-sulfonic acid; In dichloromethane; at 20 ℃; for 0.166667h;

With 3,4-dihydro-2H-pyran; In dichloromethane; at 20 ℃; for 16h;

upstream raw materials:

3,4-dihydro-2H-pyran

2-bromoethanol

4-trifluoroacetamidothiazole

sodium hydrogencarbonate

Downstream raw materials:

2-(2-((5-(benzyloxy)pentyl)oxy)ethoxy)tetrahydro-2H-pyran

2,4-dichlorophenoxyethyl tetrahydro-2H-pyran-2-yl ether

2-(4-benzylphenoxy)ethyl tetrahydro-2H-pyran-2-yl ether

4-benzyloxyphenoxyethyl tetrahydro-2H-pyran-2-yl ether

Refernces

• 1、 Moubarik, Soumaya Chraibi-Ben,Menager, Sabine,Lafont, Olivier. "Competition between the β-hydroxylation of a primary and a tertiary carbon atom in rats". . p. 97 - 106. Retrieved 2000.
• 2、 Quinton, Cassandre,Alain-Rizzo, Valérie,Dumas-Verdes, Cécile,Clavier, Gilles,Audebert, Pierre. "Original electroactive and fluorescent bichromophores based on non-conjugated tetrazine and triphenylamine derivatives: Towards more efficient fluorescent switches". . p. 49728 - 49738. Retrieved 2015.
• 3、 Aime, Silvio,Carrera, Carla,Gianolio, Eliana,Tear, Louise R.. "Towards an Improved Design of MRI Contrast Agents: Synthesis and Relaxometric Characterisation of Gd-HPDO3A Analogues". . . Retrieved 2020.
• 4、 Bouter, Caroline,Bouter, Yvonne,Breunig, Christian,Bucerius, Jan,Kremers, Sarah,Kreyenschmidt, Anne-Katrin,Mahardhika, Andhika B.,Meller, Birgit,Modemann, Daniel J.,Sahlmann, Carsten-Oliver,Stalke, Dietmar,Wiltfang, Jens,Yamoune, Sabrina,Müller, Christa E.,Maa?, Frederike. "Development of high-affinity fluorinated ligands for cannabinoid subtype 2 receptor, and in vitro evaluation of a radioactive tracer for imaging". . . Retrieved 2022/02/22.
• 5、 -. "INDAZOLE BASED COMPOUNDS AND ASSOCIATED METHODS OF USE". Paragraph 00243. . Retrieved 2021/10/02.