2-(4-benzylphenoxy)ethyl tetrahydro-2H-pyran-2-yl ether

Base Information

• Chemical Name: 2-(4-benzylphenoxy)ethyl tetrahydro-2H-pyran-2-yl ether
• CAS No.: 205381-79-9
• Molecular Formula: C₂₀H₂₄O₃
• Molecular Weight: 312.409
• Mol file: 205381-79-9.mol

Synonyms:2-(4-benzylphenoxy)ethyl tetrahydro-2H-pyran-2-yl ether

Chemical Property of 2-(4-benzylphenoxy)ethyl tetrahydro-2H-pyran-2-yl ether

Chemical Property:

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Technology Process of 2-(4-benzylphenoxy)ethyl tetrahydro-2H-pyran-2-yl ether

There total 1 articles about 2-(4-benzylphenoxy)ethyl tetrahydro-2H-pyran-2-yl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2-bromoethoxy)tetrahydropyran (17739-45-6,59146-56-4) + p-benzylphenol (101-53-1) → 2-(4-benzylphenoxy)ethyl tetrahydro-2H-pyran-2-yl ether (205381-79-9)

Guidance literature:

With potassium hydroxide; Yield given. Multistep reaction; 1.) DMSO, RT, 5 min, 2.) DMSO, RT, 5 h;

DOI:10.1021/jm970860z

Reference yield: 77.0%

2-(4-benzylphenoxy)ethyl tetrahydro-2H-pyran-2-yl ether (205381-79-9) → 2-(4-benzylphenoxy)ethanol (85983-26-2)

Guidance literature:

With pyridinium p-toluenesulfonate; In methanol; Ambient temperature;

DOI:10.1021/jm970860z

Reference yield:

2-(4-benzylphenoxy)ethyl tetrahydro-2H-pyran-2-yl ether (205381-79-9) → 2-[4-(phenylmethyl)phenoxy]ethyl 4-methylbenzenesulfonate (60225-65-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / pyridinium 4-toluenesulfonate / methanol / Ambient temperature

2: 63 percent / pyridine / 5 h / Ambient temperature

With pyridine; pyridinium p-toluenesulfonate; In methanol;

DOI:10.1021/jm970860z

upstream raw materials:

2-(2-bromoethoxy)tetrahydropyran

p-benzylphenol

Downstream raw materials:

2-(4-benzylphenoxy)ethanol

2-[4-(phenylmethyl)phenoxy]ethyl 4-methylbenzenesulfonate

Refernces