Propofol

Base Information Edit

Chemical Name:Propofol
CAS No.:2078-54-8
Deprecated CAS:28449-97-0,50356-15-5,50356-15-5
Molecular Formula:C12H18O
Molecular Weight:178.274
Hs Code.:29089990
European Community (EC) Number:218-206-6
NSC Number:758909,5105
UNII:YI7VU623SF
DSSTox Substance ID:DTXSID6023523
Nikkaji Number:J102.606B
Wikipedia:Propofol
Wikidata:Q422740
NCI Thesaurus Code:C29384
RXCUI:8782
Pharos Ligand ID:DUNCLN3HNHXJ
Metabolomics Workbench ID:43108
ChEMBL ID:CHEMBL526
Mol file:2078-54-8.mol

Synonyms:2,6 Diisopropylphenol;2,6-Bis(1-methylethyl)phenol;2,6-Diisopropylphenol;Aquafol;Diprivan;Disoprivan;Disoprofol;Fresofol;ICI 35,868;ICI 35868;ICI-35,868;ICI-35868;ICI35,868;ICI35868;Ivofol;Propofol;Propofol Abbott;Propofol Fresenius;Propofol MCT;Propofol Rovi;Propofol-Lipuro;Recofol

Suppliers and Price of Propofol

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Propofol
100g
$ 100.00

Sigma-Aldrich
2,6-Diisopropylphenol analytical standard
1ml
$ 64.70

Sigma-Aldrich
2,6-Diisopropylphenol 97%
5g
$ 25.60

Sigma-Aldrich
Propofol Pharmaceutical Secondary Standard; Certified Reference Material
1ml
$ 129.00

Sigma-Aldrich
Propofol solution 1.0?mg/mL in methanol, ampule of 1?mL, certified reference material, Cerilliant?
1 mL
$ 116.00

Sigma-Aldrich
Propofol solution 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material
076-1ml
$ 112.00

Sigma-Aldrich
2,6-Diisopropylphenol 97%
100g
$ 104.00

Sigma-Aldrich
Propofol European Pharmacopoeia (EP) Reference Standard
$ 190.00

Sigma-Aldrich
Propofol for peak identification European Pharmacopoeia (EP) Reference Standard
y0000017
$ 190.00

Sigma-Aldrich
Propofol European Pharmacopoeia (EP) Reference Standard
y0000016
$ 190.00

Total 191 raw suppliers

Chemical Property of Propofol Edit

Chemical Property:

Appearance/Colour:light yellow liquid
Vapor Pressure:5.6 mm Hg ( 100 °C)
Melting Point:18 °C(lit.)
Refractive Index:n20/D 1.514(lit.)
Boiling Point:256 °C at 760 mmHg
PKA:pKa 11.10(H2O,t =20)(Approximate)
Flash Point:107.5 °C
PSA：20.23000
Density:0.948 g/cm³
LogP:3.63900
Storage Temp.:0-6°C
Solubility.:Very slightly soluble in water, miscible with hexane and with methanol
Water Solubility.:Very slightly soluble in water.
XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:178.135765193
Heavy Atom Count:13
Complexity:135

Purity/Quality:

99.5% ^*data from raw suppliers

Propofol ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn,T,F
Statements: 22-36/37/38-20/21/22-39/23/24/25-23/24/25-11
Safety Statements: 26-36/37/39-37/39-36-45-36/37-16-7

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Drug Classes:Anesthetics
Canonical SMILES:CC(C)C1=C(C(=CC=C1)C(C)C)O
Recent ClinicalTrials:Efficacy and Safety of Fospropofol Disodium Versus Propofol for Sedation in Mechanically Ventilated ICU Patients
Recent EU Clinical Trials:Evaluation of the effect of Opioid-Free Anesthesia on oxygenation in bariatric surgery
Recent NIPH Clinical Trials:A study on the efficacy of the loss of response to jaw thrust as a clinical test to assess adequate depth of anesthesia using remimazolam besylate and the dose required for the loss of response.
Description Propofol is an injectable, short-acting general anesthetic with a low incidence of side effects.
Uses A anesthetic used in veterinary medicine Propofol is an anesthetic used in veterinary medicine. 2,6-DIPP is the active ingredient for intravenous anesthetic formulations, also has applications as an intermediate for polymers
Biological Functions Propofol (Diprivan) is rapidly acting, has a short recovery time, and possesses antiemetic properties. A rapid onset of anesthesia (50 seconds) is achieved, and if no other drug is administered, recovery will take place in 4 to 8 minutes.The recovery is attributed to redistribution of the drug and rapid metabolism to glucuronide and sulfate conjugates by the liver and extrahepatic tissues, such as intestine and kidney. Rapid recovery and its antiemetic properties make propofol anesthesia very popular as an induction agent for outpatient anesthesia. Propofol can also be used to supplement inhalational anesthesia in longer procedures. Both continuous infusion of propofol for conscious sedation and with opioids for the maintenance of anesthesia for cardiac surgery are acceptable techniques.
Clinical Use Generic formulations of propofol may contain sodiummetabisulfite as the antimicrobial agent, and patients allergicto sulfites, especially asthmatic patients, should avoid thisformulation. Aseptic technique must be followed and unusedportions of the drug must be discarded according to the manufacturer’s instructions to prevent microbial contaminationand possible sepsis.

Technology Process of Propofol

There total 62 articles about Propofol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 91561-75-0
4-Chloropropofol

: 2078-54-8
2,6-diisopropylphenol

Guidance literature:: 4-Chloropropofol; With hydrogen; sodium hydroxide; 5%-palladium/activated carbon; In water; at 20 - 25 ℃; under 2250.23 - 3750.38 Torr;

With hydrogenchloride; In water;