2-(4-Fluorophenyl)furan

Base Information

• Chemical Name: 2-(4-Fluorophenyl)furan
• CAS No.: 58861-45-3
• Molecular Formula: C10H7FO
• Molecular Weight: 162.163
• Mol file: 58861-45-3.mol

Synonyms:2-p-Fluorphenylfuran;

Chemical Property of 2-(4-Fluorophenyl)furan

Chemical Property:

• Melting Point: 86-88℃
• Boiling Point: 220.274 °C at 760 mmHg
• Flash Point: 87.019 °C
• PSA: 13.14000
• Density: 1.144 g/cm³
• LogP: 3.08570

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-Fluorophenyl)furan

There total 21 articles about 2-(4-Fluorophenyl)furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-(4-fluorophenyl)buta-2,3-dien-1-one (1223611-91-3) → 2-(4-fluorophenyl)furan (58861-45-3)

Guidance literature:

With Au-TiO₂; acetic acid; In dichloromethane; at 25 ℃; for 0.166667h;

DOI:10.1021/acs.orglett.9b01869

Reference yield: 90.0%

fur-2-ylboronic acid (13331-23-2) + 1-Bromo-4-fluorobenzene (460-00-4) → 2-(4-fluorophenyl)furan (58861-45-3)

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 90 ℃; for 2h; Inert atmosphere;

Reference yield: 70.0%

2-furylmagnesium bromide (98754-48-4) + 4-flourophenylmagnesium bromide (352-13-6) → 2-(4-fluorophenyl)furan (58861-45-3) + 4,4'-difluorobiphenyl (398-23-2)

Guidance literature:

2-furylmagnesium bromide; 4-flourophenylmagnesium bromide; With lithium chloride; manganese(ll) chloride; In tetrahydrofuran; at -10 ℃; Inert atmosphere;

With oxygen; In tetrahydrofuran; at 10 - 20 ℃;

DOI:10.1002/ejoc.201700007

upstream raw materials:

4-amino-o-xylene

1-ethoxythiocarbonylsulfanyl-4-(4-fluorophenyl)-4-oxobutyl 2,2-dimethylpropionate

2-ethynyl-2-(4-fluorophenyl)oxirane

water

Downstream raw materials:

2-[5-(4-fluorophenyl)furan-2-yl]-3-[methyl(propan-2-yl)amino]quinoxaline-6-carboxylic acid

methyl 2-[5-(4-fluorophenyl)furan-2-yl]-3-[methyl(propan-2-yl)amino]quinoxaline-6-carboxylate

2-[5-(4-fluorophenyl)furan-2-yl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

1-[5-(4-fluorophenyl)-2-furanyl]-2-chloroethanone

Refernces

• 1、 Annes, Sesuraj Babiola,Ramesh, Subburethinam,Saravanan, Subramanian,Saritha, Rajendhiran. "Carbazole based Electron Donor Acceptor (EDA) catalysis for the synthesis of biaryl and aryl-heteroaryl compounds". supporting information. p. 2510 - 2515. Retrieved 2020/04/15.
• 2、 Zorba, Leandros,Kidonakis, Marios,Saridakis, Iakovos,Stratakis, Manolis. "Cycloisomerization of Conjugated Allenones into Furans under Mild Conditions Catalyzed by Ligandless Au Nanoparticles". supporting information. p. 5552 - 5555. Retrieved 2019/08/01.