(4'-Methoxybiphenyl-4-yl)-phenyl-methanone

Base Information

• Chemical Name: (4'-Methoxybiphenyl-4-yl)-phenyl-methanone
• CAS No.: 68294-33-7
• Molecular Formula: C20H16O2
• Molecular Weight: 288.346
• Mol file: 68294-33-7.mol

Synonyms:(4'-Methoxybiphenyl-4-yl)(phenyl)methanone;

Chemical Property of (4'-Methoxybiphenyl-4-yl)-phenyl-methanone

Chemical Property:

• Melting Point: 167-168℃
• Boiling Point: 451 °C at 760 mmHg
• Flash Point: 198.9 °C
• PSA: 26.30000
• Density: 1.122 g/cm³
• LogP: 4.59320

Purity/Quality:

99% ^*data from raw suppliers

(4'-METHOXYBIPHENYL-4-YL)-PHENYL-METHANONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (4'-Methoxybiphenyl-4-yl)-phenyl-methanone

There total 34 articles about (4'-Methoxybiphenyl-4-yl)-phenyl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-methoxyphenylboronic acid (5720-07-0) + 4-chlorobenzophenone (134-85-0) → 4-(4-methoxy-phenyl)-benzophenone (68294-33-7)

Guidance literature:

With water; palladium diacetate; cesium fluoride; cyclo-octa-1,5-diene; DavePhos; In neat (no solvent); for 1.65h; Milling; Green chemistry;

DOI:10.1039/c9sc02185j

Reference yield: 92.0%

4-(4'-hydroxyphenyl)benzophenone (5623-46-1) + methyl iodide (74-88-4) → 4-(4-methoxy-phenyl)-benzophenone (68294-33-7)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; for 0.75h;

DOI:10.1021/ja036808b

Reference yield: 91.0%

4-methoxyphenylzinc chloride (93296-09-4) + 4-chlorobenzophenone (134-85-0) → 4-(4-methoxy-phenyl)-benzophenone (68294-33-7)

Guidance literature:

With C₂₆H₂₄ClN₂NiP*0.1C₇H₈; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 80 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1039/c4ob01041h

upstream raw materials:

benzophenone

4'-methoxy-biphenyl-4-carboxylic acid

4-methoxylbiphenyl

benzoyl chloride

Downstream raw materials:

(4'-methoxybiphenyl-4-yl)diphenylmethanol

1-benzyl-4-(4-methoxyphenyl)benzene

4-(4'-hydroxyphenyl)benzophenone

4-(4-Methoxyphenyl)-diphenylmethylchlorid

Refernces

• 1、 Cheng, Bao,Zhu, Guirong,Meng, Linghua,Wu, Guolin,Chen, Qin,Ma, Shengming. "Identification and optimization of biphenyl derivatives as novel tubulin inhibitors targeting colchicine-binding site overcoming multidrug resistance". . . Retrieved 2021/11/22.
• 2、 Seo, Tamae,Ishiyama, Tatsuo,Kubota, Koji,Ito, Hajime. "Solid-state Suzuki-Miyaura cross-coupling reactions: Olefin-accelerated C-C coupling using mechanochemistry". . p. 8202 - 8210. Retrieved 2019/09/19.