Benzeneethanamine, N-hydroxy-3,4-dimethoxy-a-methyl-

Base Information

• Chemical Name: Benzeneethanamine, N-hydroxy-3,4-dimethoxy-a-methyl-
• CAS No.: 58380-00-0
• Molecular Formula: C11H17NO3
• Molecular Weight: 211.25758
• Mol file: 58380-00-0.mol

Synonyms:DL-2-Hydroxylamino-1-(3,4-dimethoxy-phenyl)-propan;1-(3,4-dimethoxyphenyl)-2-hydroxylaminopropane;N-[2-(3,4-Dimethoxy-phenyl)-1-methyl-ethyl]-hydroxylamine;N-Hydroxy-3,4-dimethoxy-amphetamin;

Chemical Property of Benzeneethanamine, N-hydroxy-3,4-dimethoxy-a-methyl-

Chemical Property:

• PSA: 50.72000
• LogP: 2.00450

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneethanamine, N-hydroxy-3,4-dimethoxy-a-methyl-

There total 6 articles about Benzeneethanamine, N-hydroxy-3,4-dimethoxy-a-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3,4-dimethoxy-phenyl)-acetone oxime (1454-62-2) → N-(1-methyl-2-(3,4-dimethoxy-phenyl)ethyl)hydroxylamine (58380-00-0)

Guidance literature:

With hydrogenchloride; sodium cyanoborohydride;

DOI:10.1016/0040-4020(75)80276-6

Reference yield:

3,4-dimethoxy-benzaldehyde (120-14-9) → N-(1-methyl-2-(3,4-dimethoxy-phenyl)ethyl)hydroxylamine (58380-00-0)

Guidance literature:

Multi-step reaction with 4 steps

1: NH₄OAc / acetic acid

2: Fe, FeCl₃, aq. HCl

3: aq. NH₂OH*HCl, Na₂CO₃

4: NaBH₃CN, aq. HCl

With hydrogenchloride; hydroxylamine hydrochloride; ammonium acetate; iron(III) chloride; iron; sodium cyanoborohydride; sodium carbonate; In acetic acid;

DOI:10.1016/0040-4020(75)80276-6

Reference yield:

3,4-dimethoxyphenylacetone (776-99-8) → N-(1-methyl-2-(3,4-dimethoxy-phenyl)ethyl)hydroxylamine (58380-00-0)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NH₂OH*HCl, Na₂CO₃

2: NaBH₃CN, aq. HCl

With hydrogenchloride; hydroxylamine hydrochloride; sodium cyanoborohydride; sodium carbonate;

DOI:10.1016/0040-4020(75)80276-6

upstream raw materials:

2-(3,4-dimethoxyphenyl)-1-methylethylamine

(3,4-dimethoxy-phenyl)-acetone oxime

3,4-dimethoxyphenylacetone

(E)-1,2-dimethoxy-4-(2-nitroprop-1-enyl)benzene

Downstream raw materials:

N-Hydroxy-N-benzyl-3,4-dimethoxy-amphetamin

α-Phenyl-N-(1-<3',4'-dimethoxyphenyl>prop-2-yl)-nitron

N-(1-<3',4'-Dimethoxyphenyl>prop-2-yl)-nitron

Refernces