3,4-Dimethoxyamphetamine

Base Information

• Chemical Name: 3,4-Dimethoxyamphetamine
• CAS No.: 120-26-3
• Molecular Formula: C11H17 N O2
• Molecular Weight: 195.261
• Hs Code.: 2922299090
• European Community (EC) Number: 204-383-7
• UNII: EMH5PUB78V
• DSSTox Substance ID: DTXSID50902787
• Nikkaji Number: J273.466D
• Wikidata: Q27277248
• ChEMBL ID: CHEMBL277540
• Mol file: 120-26-3.mol

Synonyms:3,4-dimethoxyamphetamine;3,4-dimethoxyamphetamine hydrochloride;3,4-dimethoxyamphetamine hydrochloride, (+-)-isomer;3,4-dimethoxyamphetamine hydrochloride, (S)-isomer;3,4-dimethoxyamphetamine sulfate (2:1);3,4-dimethoxyamphetamine, (+-)-isomer;3,4-dimethoxyamphetamine, (R)-isomer

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of 3,4-Dimethoxyamphetamine

Chemical Property:

• Melting Point: 39-40 °C
• Boiling Point: 289°Cat760mmHg
• PKA: 9.78±0.10(Predicted)
• Flash Point: 139.8°C
• PSA: 44.48000
• Density: 1.023g/cm³
• LogP: 2.29380
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 195.125928785
• Heavy Atom Count: 14
• Complexity: 163

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CC1=CC(=C(C=C1)OC)OC)N

Technology Process of 3,4-Dimethoxyamphetamine

There total 29 articles about 3,4-Dimethoxyamphetamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-(3,4-dimethoxyphenyl)-2-nitropropene (122-47-4) → 2-(3,4-dimethoxyphenyl)-1-methylethylamine (120-26-3)

Guidance literature:

1-(3,4-dimethoxyphenyl)-2-nitropropene; With lithium aluminium tetrahydride; In tetrahydrofuran; for 1h; Heating / reflux;

With hydrogenchloride; In tetrahydrofuran; water; ethyl acetate;

With ammonia; tartaric acid; more than 3 stages;

Reference yield: 75.0%

(E)-1,2-dimethoxy-4-(2-nitroprop-1-enyl)benzene (37629-53-1) → 2-(3,4-dimethoxyphenyl)-1-methylethylamine (120-26-3)

Guidance literature:

With samarium diiodide; water; isopropylamine; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2007.05.105

Reference yield: 70.0%

N-[2-(3,4-Dimethoxy-phenyl)-1-methyl-ethyl]-2,2,2-trifluoro-acetamide (91994-62-6) → 2-(3,4-dimethoxyphenyl)-1-methylethylamine (120-26-3)

Guidance literature:

With potassium carbonate; In methanol; water; for 2h; Heating;

DOI:10.1021/jo00196a001

upstream raw materials:

1-(3,4-dimethoxyphenyl)-2-nitropropene

1,2-dimethoxy-4-(2-propenyl)benzene

3-(3,4-dimethoxy-phenyl)-2-methyl-propionic acid amide

3,4-dimethoxyphenylacetone

Downstream raw materials:

6,7-dimethoxy-3-methyl-3,4-dihydro-isoquinoline; hydrochloride

1-[2-(3,4-Dimethoxy-phenyl)-1-methyl-ethylamino]-3-{2-[(E)-2-(3-methyl-isoxazol-5-yl)-vinyl]-phenoxy}-propan-2-ol

N-[2-(3,4-dimethoxy-phenyl)-1-methyl-ethyl]-acetamide

N-(1-methyl-2-(3,4-dimethoxy-phenyl)ethyl)hydroxylamine

Refernces

• 1、 González-Martínez, Daniel,Gotor, Vicente,Gotor-Fernández, Vicente. "Stereoselective Synthesis of 1-Arylpropan-2-amines from Allylbenzenes through a Wacker-Tsuji Oxidation-Biotransamination Sequential Process". . p. 2582 - 2593. Retrieved 2019/05/15.
• 2、 -. "NOVEL DIHYDROQUINOLIZINONES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION". Page/Page column 116; 117. . Retrieved 2015/09/23.