2,3-diMethyl-2-(triMethylsilyloxy)butanenitrile

Base Information

• Chemical Name: 2,3-diMethyl-2-(triMethylsilyloxy)butanenitrile
• CAS No.: 883726-88-3
• Molecular Formula: C9H19NOSi
• Molecular Weight: 185
• Hs Code.: 2931900090
• Mol file: 883726-88-3.mol

Synonyms:2,3-dimethyl-2-[(trimethylsilyl)oxy]butanenitrile;

Chemical Property of 2,3-diMethyl-2-(triMethylsilyloxy)butanenitrile

Chemical Property:

• PSA: 33.02000
• LogP: 2.77618
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2,3-Dimethyl-2-(trimethylsilyloxy)butanenitrile 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3-diMethyl-2-(triMethylsilyloxy)butanenitrile

There total 1 articles about 2,3-diMethyl-2-(triMethylsilyloxy)butanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-methyl-butan-2-one (563-80-4) + trimethylsilyl cyanide (7677-24-9) → 2,3-dimethyl-2-((trimethylsilyl)oxy)butanenitrile (883726-88-3)

Guidance literature:

With trans-{(ⁱBu)₂ATIGeⁱPr}₂Pt(CN)₂; In chloroform-d1; at 50 ℃; for 6h; Catalytic behavior; Schlenk technique; Glovebox;

DOI:10.1039/c8dt00043c

Reference yield:

2,3-dimethyl-2-((trimethylsilyl)oxy)butanenitrile (883726-88-3) → (+/-)-2-hydroxy-2,3-dimethylbutanenitrile (4111-10-8)

Guidance literature:

With camphor-10-sulfonic acid; water; In 2-methyltetrahydrofuran; at 23 ℃; for 3h; Inert atmosphere;

DOI:10.1021/jo900287b

Reference yield:

2,3-dimethyl-2-((trimethylsilyl)oxy)butanenitrile (883726-88-3) → (R)-(-)-2-hydroxy-2,3-dimethylbutanoic acid (92735-50-7) + (S)-(+)-2-hydroxy-2,3-dimethylbutanoic acid (78640-99-0)

Guidance literature:

With hydrogenchloride; water; at 85 ℃; for 16h; optical yield given as %ee;

DOI:10.1021/jo900287b

upstream raw materials:

3-methyl-butan-2-one

trimethylsilyl cyanide

Downstream raw materials:

4-amino-5-isopropyl-5-methyl-2(5H)-furanone

(R)-(-)-2-hydroxy-2,3-dimethylbutanoic acid

(S)-(+)-2-hydroxy-2,3-dimethylbutanoic acid

(+/-)-2-hydroxy-2,3-dimethylbutanenitrile

Refernces

• 1、 Sharma, Mahendra Kumar,Singh, Dharmendra,Mahawar, Pritam,Yadav, Ravi,Nagendran, Selvarajan. "Catalytic cyanosilylation using germylene stabilized platinum(ii) dicyanide". supporting information. p. 5943 - 5947. Retrieved 2018/05/14.
• 2、 Bisai, Milan Kumar,Das, Tamal,Vanka, Kumar,Sen, Sakya S.. "Easily accessible lithium compound catalyzed mild and facile hydroboration and cyanosilylation of aldehydes and ketones". supporting information. p. 6843 - 6846. Retrieved 2018/06/26.