92735-50-7

Basic information

• Product Name: Butanoic acid, 2-hydroxy-2,3-dimethyl-, (R)-
• CAS NO: 92735-50-7
• Molecular Formula: C6H12O3
• Molecular Weight: 132.159
• Mol File: 92735-50-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 2-hydroxy-2,3-dimethyl-, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 2-hydroxy-2,3-dimethyl-, (R)-(92735-50-7)
• EPA Substance Registry System: Butanoic acid, 2-hydroxy-2,3-dimethyl-, (R)-(92735-50-7)

Safety Data

• Hazardous Substances Data: 92735-50-7(Hazardous Substances Data)

Upstream product

• 883726-88-3 2,3-dimethyl-2-((trimethylsilyl)oxy)butanenitrile 
• 805228-82-4 (R)-2,3-dimethyl-2-(trimethylsilyloxy)butanenitrile 
• 563-80-4 3-methyl-butan-2-one 
• 74-90-8 hydrogen cyanide 

Relevant articles and documents

(αMe)Hyv: Chemo-enzymatic synthesis, and preparation and preferred conformation of model depsipeptides

By a chemo-enzymatic approach we performed a large-scale, stereoselective synthesis of the Cα-methylated α-hydroxy acid L-(αMe)Hyv. We also prepared model depsipeptides based on this sterically demanding residue in combination with the α-amino

Enzyme-catalyzed synthesis of (R)-ketone-cyanohydrins and their hydrolysis to (R)-α-hydroxy-α-methyl-carboxylic acids

(R)-Ketone-cyanohydrins (R)-2 are obtained with high enantioselectivity from aliphatic ketones 1 and HCN in organic solvents using (R)-oxynitrilase ( EC 4.1.2.10) as catalyst. Acid catalyzed hydrolysis of the cyanohydrins (R)-2 affords the corresponding (R)-α-hydroxy-α-methyl-carboxylic acids (R)-3 without measurable racemization.