4-(Pyridin-3-yl)phenylboronic acid

Base Information

• Chemical Name: 4-(Pyridin-3-yl)phenylboronic acid
• CAS No.: 170230-28-1
• Molecular Formula: C11 H10BNO2
• Molecular Weight: 199.08
• Mol file: 170230-28-1.mol

Synonyms:4-(pyridin-3-yl)phenylboronic acid;4-(3-Pyridinyl)phenylboronic acid

Chemical Property of 4-(Pyridin-3-yl)phenylboronic acid

Chemical Property:

• Boiling Point: 411.7±47.0 °C(Predicted)
• PKA: 7.91±0.10(Predicted)
• PSA: 53.35000
• Density: 1.24±0.1 g/cm3 (20 oC 760 Torr)
• LogP: 0.42840
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

(4-(Pyridin-3-yl)phenyl)boronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(Pyridin-3-yl)phenylboronic acid

There total 6 articles about 4-(Pyridin-3-yl)phenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.15%

3-(4-bromophenyl)pyridine (129013-83-8) + Triisopropyl borate (5419-55-6) → (4-(pyridin-3-yl)phenyl)boronic acid (170230-28-1)

Guidance literature:

3-(4-bromophenyl)pyridine; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 0.166667h; Inert atmosphere;

Triisopropyl borate; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;

Reference yield: 65.0%

3-(4-bromophenyl)pyridine (129013-83-8) + Trimethyl borate (121-43-7,63156-11-6) → (4-(pyridin-3-yl)phenyl)boronic acid (170230-28-1)

Guidance literature:

3-(4-bromophenyl)pyridine; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h;

Trimethyl borate; In tetrahydrofuran; at 20 ℃;

Reference yield:

3-(4-bromophenyl)pyridine (129013-83-8) + triethyl borate (150-46-9) → (4-(pyridin-3-yl)phenyl)boronic acid (170230-28-1)

Guidance literature:

3-(4-bromophenyl)pyridine; With Bu-Li; In diethyl ether; at -78 ℃; for 2h; Inert atmosphere;

triethyl borate; In diethyl ether; at -78 - 20 ℃; for 8.5h;

upstream raw materials:

3-pyridylboronic acid

3-(4-bromophenyl)pyridine

triethyl borate

1.4-dibromobenzene

Downstream raw materials:

4,4''-di(3-pyridyl)-4',5'-bis[4-(3-pyridyl)phenyl]-1,1':2',1''-terphenyl

Refernces

• 1、 -. "Bipyridyl derivative and application thereof". Paragraph 0082; 0087-0089. . Retrieved 2019/08/06.