Indacrinone

Base Information

• Chemical Name: Indacrinone
• CAS No.: 57296-63-6
• Molecular Formula: C₁₈H₁₄Cl₂O₄
• Molecular Weight: 365.213
• Mol file: 57296-63-6.mol

Synonyms:Indacrinone;Indacrinic acid;Indacrynic acid;MK-196;[(6,7-Dichloro-2-methyl-1-oxo-2-phenyl-2,3-dihydro-1H-inden-5-yl) oxy]acetic acid

Chemical Property of Indacrinone

Chemical Property:

• Melting Point: 167.5°C
• Refractive Index: 1.5300 (estimate)
• Boiling Point: 481.19°C (rough estimate)
• PSA: 63.60000
• Density: 1.2589 (rough estimate)
• LogP: 4.15350

Purity/Quality:

99% ^*data from raw suppliers

INDACRINONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Indacrinone

There total 21 articles about Indacrinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

((S)-6,7-Dichloro-2-methyl-1-oxo-2-phenyl-indan-5-yloxy)-acetic acid ethyl ester (88440-75-9) → S-(+)-indacrinone (57297-16-2,57296-63-6)

Guidance literature:

With hydrogenchloride; sodium hydroxide; In toluene; Yield given; Heating;

DOI:10.1021/ja00314a045

Reference yield:

(S)-6,7-Dichloro-5-hydroxy-2-methyl-2-phenyl-indan-1-one (57296-65-8,57509-50-9,76640-83-0,76640-84-1) → S-(+)-indacrinone (57297-16-2,57296-63-6)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃, NaI / toluene / Heating

2: NaOH, HCl / toluene / Heating

With hydrogenchloride; sodium hydroxide; potassium carbonate; sodium iodide; In toluene;

DOI:10.1021/ja00314a045

Reference yield:

(S)-(+)-6,7-dichloro-5-methoxy-2-methyl-2-phenyl-1-indanone (88494-66-0) → S-(+)-indacrinone (57297-16-2,57296-63-6)

Guidance literature:

Multi-step reaction with 3 steps

1: AlCl₃ / toluene / 45 °C

2: K₂CO₃, NaI / toluene / Heating

3: NaOH, HCl / toluene / Heating

With hydrogenchloride; sodium hydroxide; aluminium trichloride; potassium carbonate; sodium iodide; In toluene;

DOI:10.1021/ja00314a045

upstream raw materials:

6,7-dichloro-2,3-dihydro-5-hydroxy-2-methyl-2-phenyl-1H-inden-1-one

ethyl bromoacetate

(1-oxo-2-phenyl-6,7-dichloro-5-indanyloxy)acetic acid

methyl iodide

Downstream raw materials:

[1-oxo-2-methyl-2-(4-sulfamoylphenyl)-6,7-dichloro-5-indanyloxy]acetic acid

Refernces

• 1、 -. "(1-Oxo-2-aryl or thienyl-2-substituted-5-indanyloxy (or thio) alkanoic acids, and derivatives thereof". . . Retrieved 2008/06/13.