MONO-METHYL POLYETHYLENE GLYCOL 20'000 2-(SUCCINYL-AMINO)ETHYL ETHER

Base Information

• Chemical Name: MONO-METHYL POLYETHYLENE GLYCOL 20'000 2-(SUCCINYL-AMINO)ETHYL ETHER
• CAS No.: 92450-99-2
• Molecular Formula: C₁₅H₂₉NO₈
• Molecular Weight: 351.397
• Mol file: 92450-99-2.mol

Synonyms:MONO-METHYL POLYETHYLENE GLYCOL 20,000 2-(SUCCINYLAMINO)ETHYL ETHER;MONO-METHYL POLYETHYLENE GLYCOL 20'000 2-(SUCCINYL-AMINO)ETHYL ETHER;O-[2-(3-SUCCINYLAMINO)ETHYL]-O'-METHYL-POLYETHYLENE GLYCOL 20,000;O-[2-(3-SUCCINYLAMINO)ETHYL]-O'-METHYL-POLYETHYLENE GLYCOL 20'000;O-[2-(3-succinylamino)ethyl]-O'-methyl-peg 20'000;O-(2-(3-SUCCINYLAMINO)ETHYL)-O'-METHYL-;O-[2-(3-Succinylamino)ethyl]-Oμ-methyl-polyethylene glycol

Chemical Property of MONO-METHYL POLYETHYLENE GLYCOL 20'000 2-(SUCCINYL-AMINO)ETHYL ETHER

Chemical Property:

• PSA: 128.81000
• LogP: -0.55830
• Storage Temp.: −20°C

Purity/Quality:

98%min ^*data from raw suppliers

O-[2-(3-Succinylamino)ethyl]-O′-methyl-polyethylene glycol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Reactant for:? ;Preparation of supramolecular ABC triblock copolymers via orthogonal self-assembly1? ;Filamentous condensation of DNA for transfection studies2 O-[2-(3-Succinylamino)ethyl]-O''-methyl-polyethylene Glycol aids in the surface functionalization of MOF particles, which is important in biomedical applications. Reactant for:Preparation of supramolecular ABC triblock copolymers via orthogonal self-assemblyFilamentous condensation of DNA for transfection studies

Technology Process of MONO-METHYL POLYETHYLENE GLYCOL 20'000 2-(SUCCINYL-AMINO)ETHYL ETHER

There total 6 articles about MONO-METHYL POLYETHYLENE GLYCOL 20'000 2-(SUCCINYL-AMINO)ETHYL ETHER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

succinic acid anhydride (108-30-5) + 2,5,8,11,14-pentaoxahexadecane-16-amine (5498-83-9,80506-64-5,869718-87-6) → 18-oxo-2,5,8,11,14-pentaoxa-17-azahenicosan-21-oic acid (92450-99-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 15.5h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.0c01153

Reference yield:

triethylene glucol monomethyl ether (112-35-6,95507-80-5) → 18-oxo-2,5,8,11,14-pentaoxa-17-azahenicosan-21-oic acid (92450-99-2)

Guidance literature:

Multi-step reaction with 6 steps

1: triethylamine; dmap / dichloromethane / 8 h / 20 °C / Inert atmosphere

2: sodium hydride / tetrahydrofuran / 15 h / 80 °C / Inert atmosphere

3: triethylamine; dmap / dichloromethane / 5 h / 20 °C / Inert atmosphere

4: sodium azide / N,N-dimethyl-formamide / 11.5 h / 80 °C / Inert atmosphere

5: hydrogen; palladium on activated charcoal / methanol / 2 h / 20 °C

6: triethylamine / dichloromethane / 15.5 h / 20 °C / Inert atmosphere

With dmap; sodium azide; palladium on activated charcoal; hydrogen; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.0c01153

Reference yield:

2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate (62921-74-8,518012-62-9,58320-73-3) → 18-oxo-2,5,8,11,14-pentaoxa-17-azahenicosan-21-oic acid (92450-99-2)

Guidance literature:

Multi-step reaction with 5 steps

1: sodium hydride / tetrahydrofuran / 15 h / 80 °C / Inert atmosphere

2: triethylamine; dmap / dichloromethane / 5 h / 20 °C / Inert atmosphere

3: sodium azide / N,N-dimethyl-formamide / 11.5 h / 80 °C / Inert atmosphere

4: hydrogen; palladium on activated charcoal / methanol / 2 h / 20 °C

5: triethylamine / dichloromethane / 15.5 h / 20 °C / Inert atmosphere

With dmap; sodium azide; palladium on activated charcoal; hydrogen; sodium hydride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/acs.jmedchem.0c01153

upstream raw materials:

triethylene glucol monomethyl ether

2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate

3,6,9,12,15-pentaoxahexadecanol

3,6,9,12,15-pentaoxahexadecyl tosylate

Downstream raw materials:

C₁₉H₃₂N₂O₁₀

Refernces