LRRK2-kinase inhibitor

Base Information

• Chemical Name: LRRK2-kinase inhibitor
• CAS No.: 1285515-21-0
• Molecular Formula: C24H18FN3O2
• Molecular Weight: 399.424
• Mol file: 1285515-21-0.mol

Synonyms:LRRK2-kinase inhibitor;BenzaMide, 5-(2-fluoro-4-pyridinyl)-2-(phenylMethoxy)-N-3-pyridinyl-;GSK2578215A;5-(2-Fluoro-4-pyridinyl)-2-(phenylmethoxy)-N-3-pyridinylbenzamide;2-(benzyloxy)-5-(2-fluoropyridin-4-yl)-N-(pyridin-3-yl)benzaMide;5-(2-Fluoro-4-pyridinyl)-2-(phenylmethoxy)-N-3-pyridinylbenzamide GSK2578215A;5-(2-fluoro-4-pyridinyl)-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide;GSK2578125A

Chemical Property of LRRK2-kinase inhibitor

Chemical Property:

• Boiling Point: 556.1±50.0 °C(Predicted)
• PKA: 12.31±0.70(Predicted)
• PSA: 67.60000
• Density: 1.292±0.06 g/cm3(Predicted)
• LogP: 5.49800
• Storage Temp.: 2-8°C
• Solubility.: DMSO: soluble15mg/mL, clear

Purity/Quality:

99% ^*data from raw suppliers

GSK2578215A ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: GSK2578215A is a potent, selective LRRK2 inhibitor and a promising therapeutic for treating Parkinson''s disease.

Technology Process of LRRK2-kinase inhibitor

There total 5 articles about LRRK2-kinase inhibitor which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.2%

5-bromo-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide (1285513-32-7) + 2-fluoropyridin-4-ylboronic acid (401815-98-3) → GSK-2578215A (1285515-21-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,2-dimethoxyethane; water; for 2h; Reflux;

DOI:10.1016/j.bmcl.2017.07.052

Reference yield:

5-bromosalicyclic acid (89-55-4) → GSK-2578215A (1285515-21-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium carbonate / acetone / 70 °C

2.1: water; lithium hydroxide / tetrahydrofuran / 71 °C

2.2: pH 2

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C / Inert atmosphere

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 2 h / Reflux

With water; sodium carbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; acetone;

Reference yield:

5-bromo-2-[(phenylmethyl)oxy]benzoic acid (62176-31-2) → GSK-2578215A (1285515-21-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 20 °C / Inert atmosphere

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 2 h / Reflux

With sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; water;

upstream raw materials:

5-bromosalicyclic acid

5-bromo-2-[(phenylmethyl)oxy]-N-3-pyridinylbenzamide

2-fluoropyridin-4-ylboronic acid

5-bromo-2-[(phenylmethyl)oxy]benzoic acid

Refernces

• 1、 -. "NOVEL COMPOUNDS". . . Retrieved 2011/04/25.