NORMORPHINE HYDROCHLORIDE METHANOL*SOLUT ION 100 MIC

Base Information

• Chemical Name: NORMORPHINE HYDROCHLORIDE METHANOL*SOLUT ION 100 MIC
• CAS No.: 3372-02-9
• Molecular Formula: C16H17NO3.ClH.H2O
• Molecular Weight: 307.777
• Mol file: 3372-02-9.mol

Synonyms:NORMORPHINE HYDROCHLORIDE METHANOL*SOLUT ION 100 MIC;normorphine hydrochloride*monohydrate--dea schedu;(5alpha,6alpha)-7,8-didehydro-4,5-epoxymorphinan-3,6-diol hydrochloride;Normorphine hydrochloride;Normorphine hydrochloride monohydrate

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Chemical Property of NORMORPHINE HYDROCHLORIDE METHANOL*SOLUT ION 100 MIC

Chemical Property:

• Vapor Pressure: 2.99E-10mmHg at 25°C
• Boiling Point: 485.8°C at 760 mmHg
• Flash Point: 247.6°C
• PSA: 61.72000
• Density: 1.48g/cm³
• LogP: 1.98670
• Storage Temp.: ?20°C

Purity/Quality:

Safty Information:

• Hazard Codes: Xn,T,F
• Statements: 22-39/23/24/25-23/24/25-11
• Safety Statements: 36/37/39-45-36/37-16-7

MSDS Files:

Useful:

Technology Process of NORMORPHINE HYDROCHLORIDE METHANOL*SOLUT ION 100 MIC

There total 3 articles about NORMORPHINE HYDROCHLORIDE METHANOL*SOLUT ION 100 MIC which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

morphine-N-oxide hydrochloride (1234788-64-7) → Normorphine hydrochloride (3372-02-9) + MORPHIN (57-27-2)

Guidance literature:

With iron(III) chloride hexahydrate; iron; In chloroform; isopropyl alcohol; at 40 ℃; for 48h;

DOI:10.1071/CH11320

Reference yield: 58.0%

morphine-N-oxide hydrochloride (1234788-64-7) → morphine hydrochloride (52-26-6) + Normorphine hydrochloride (3372-02-9)

Guidance literature:

With iron; In isopropyl alcohol; at 40 ℃; Inert atmosphere;

DOI:10.1021/jo1008492

Reference yield:

MORPHIN (57-27-2) → Normorphine hydrochloride (3372-02-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 3-chloro-benzenecarboperoxoic acid / chloroform; isopropyl alcohol / 0.42 h / -5 °C

2: iron(III) chloride hexahydrate; iron / chloroform; isopropyl alcohol / 48 h / 40 °C

With iron(III) chloride hexahydrate; iron; 3-chloro-benzenecarboperoxoic acid; In chloroform; isopropyl alcohol;

DOI:10.1071/CH11320

upstream raw materials:

morphine-N-oxide hydrochloride

MORPHIN

Downstream raw materials:

normorphine

Refernces

• 1、 Kok, Gaik B.,Pye, Cory C.,Singer, Robert D.,Scammells, Peter J.. "Two-step iron(0)-mediated N-demethylation of N -methyl alkaloids". experimental part. p. 4806 - 4811. Retrieved 2010/10/19.