3-(Boc-amino)-3-methylpip...

Base Information

• Chemical Name: 3-(Boc-amino)-3-methylpip...
• CAS No.: 169750-96-3
• Molecular Formula: C11H22N2O2
• Molecular Weight: 214.30458
• Hs Code.: 2933399990
• Mol file: 169750-96-3.mol

Synonyms:3-(Boc-amino)-3-methylpip...;3-(Boc-aMino)-3-Methylpiperidine;3-Amino-3-methylpiperidine, 3-BOC protected;tert-Butyl (3-methylpiperidin-3-yl)carbamate, 3-[(tert-Butoxycarbonyl)amino]-3-methylpiperidine;(3-Methyl-3-piperidinyl)carbamic acid 1,1-dimethylethyl ester;tert-Butyl 3-methylpiperidin-3-yl-carbamate;tert-butyl n-(3-methylpiperidin-3-yl)carbamate

Chemical Property of 3-(Boc-amino)-3-methylpip...

Chemical Property:

• Boiling Point: 308.4±31.0 °C(Predicted)
• PKA: 12?+-.0.20(Predicted)
• PSA: 50.36000
• Density: 1.01±0.1 g/cm3(Predicted)
• LogP: 2.37290
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-(Boc-amino)-3-methylpiperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(Boc-amino)-3-methylpip...

There total 5 articles about 3-(Boc-amino)-3-methylpip... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

rac-benzyl 3-((tert-butoxycarbonyl)amino)-3-methylpiperidine-1-carboxylate (1196506-86-1) → tert-butyl N-(3-methyl-3-piperidinyl)carbamate (169750-96-3)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In ethanol; at 220 ℃; for 2h; Inert atmosphere;

Reference yield:

3-ethyl 1-(phenylmethyl) 1,3-piperidinedicarboxylate (310454-53-6) → tert-butyl N-(3-methyl-3-piperidinyl)carbamate (169750-96-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.33 h / -78 °C

1.2: -78 - 20 °C

2.1: water; lithium hydroxide / ethanol / 1 h / 86 °C

2.2: pH 3 - 4

3.1: diphenyl phosphoryl azide; triethylamine / 6 h / Heating; Reflux

3.2: 72 h / 126 °C / sealed tube

4.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 760.05 Torr

With diphenyl phosphoryl azide; water; hydrogen; triethylamine; lithium hydroxide; lithium hexamethyldisilazane; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol;

Reference yield:

1-benzyl 3-ethyl 3-methylpiperidine-1,3-dicarboxylate (664364-60-7) → tert-butyl N-(3-methyl-3-piperidinyl)carbamate (169750-96-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: water; lithium hydroxide / ethanol / 1 h / 86 °C

1.2: pH 3 - 4

2.1: diphenyl phosphoryl azide; triethylamine / 6 h / Heating; Reflux

2.2: 72 h / 126 °C / sealed tube

3.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 760.05 Torr

With diphenyl phosphoryl azide; water; hydrogen; triethylamine; lithium hydroxide; palladium 10% on activated carbon; In methanol; ethanol;

upstream raw materials:

rac-benzyl 3-((tert-butoxycarbonyl)amino)-3-methylpiperidine-1-carboxylate

3-ethyl 1-(phenylmethyl) 1,3-piperidinedicarboxylate

1-benzyl 3-ethyl 3-methylpiperidine-1,3-dicarboxylate

1-((benzyloxy)carbonyl)-3-methylpiperidine-3-carboxylic acid

Refernces

• 1、 -. "PYRROLOPYRIDINES AS KINASE INHIBITORS". Page/Page column 73. . Retrieved 2009/12/23.