Epinastine

Base Information Edit

Chemical Name:Epinastine
CAS No.:80012-43-7
Deprecated CAS:134507-59-8
Molecular Formula:C16H15N3
Molecular Weight:249.315
Hs Code.:
European Community (EC) Number:616-785-3
UNII:Q13WX941EF
DSSTox Substance ID:DTXSID2048371
Nikkaji Number:J22.791I
Wikipedia:Epinastine
Wikidata:Q632405
NCI Thesaurus Code:C65515
RXCUI:39684
Pharos Ligand ID:C3WCM77A47C3
Metabolomics Workbench ID:145485
ChEMBL ID:CHEMBL1106
Mol file:80012-43-7.mol

Synonyms:3-amino-9,13b-dihydro-1H-benz(c,f)imidazo(1,5a)azepine;epinastine;epinastine hydrochloride;Flurinol;WAL 80;WAL 801;WAL 801 CL;WAL 801CL;WAL-80 Cl

Suppliers and Price of Epinastine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Epinastine
100mg
$ 600.00

CSNpharm
Epinastine
50mg
$ 77.00

Crysdot
Epinastine 98+%
100mg
$ 132.00

ChemScene
Epinastine ≥98.0%
50mg
$ 96.00

ChemScene
Epinastine ≥98.0%
100mg
$ 132.00

ChemScene
Epinastine ≥98.0%
500mg
$ 540.00

AvaChem
Epinastine
100mg
$ 329.00

AvaChem
Epinastine
10mg
$ 159.00

Arctom
9,13B-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-3-amine ≥98%
100mg
$ 115.00

Arctom
9,13B-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-3-amine ≥98%
50mg
$ 64.00

Total 102 raw suppliers

Chemical Property of Epinastine Edit

Chemical Property:

Appearance/Colour:white to yellow crystalline powder
Vapor Pressure:1.56E-07mmHg at 25°C
Melting Point:270oC
Refractive Index:1.727
Boiling Point:428 °C at 760 mmHg
PKA:11.2(at 25℃)
Flash Point:212.7 °C
PSA：41.62000
Density:1.32 g/cm³
LogP:2.66770
Storage Temp.:Keep in dark place,Inert atmosphere,Room temperature
XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:0
Exact Mass:249.126597491
Heavy Atom Count:19
Complexity:378

Purity/Quality:

99% ^*data from raw suppliers

Epinastine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C2C3=CC=CC=C3CC4=CC=CC=C4N2C(=N1)N
Recent ClinicalTrials:A Study of Epinastine Nasal Spray in Subjects With Seasonal Allergic Rhinitis
Recent NIPH Clinical Trials:Transfer of epinastine to infants through human breast milk
Description Epinastine hydrochloride, an orally active antihistaminic agent, was marketed in Japan for the treatment of bronchial asthma, allergic rhinitis, urticaria, eczema, dermatitis, and psoriasis vulgaris.Epinastine is one of the most effective peripherally acting histamine H1-receptor antagonists without sedative effects.In addition, it exhibits potent anti-PAF and anti-LT activity which may also contribute significantly to its antiallergic activity. Chronic epinastine has been reported to effectively inhibit airway hyper-responsiveness in rats. Potent inhibitory effects of epinastine on bronchoconstriction induced by histamine and bradykinin, but not by other chemical mediators, has also been reported. Studies have indicated that there are no significant differences in pharmacological properties among D-, L-, and racemic epinastine.
Uses Epinastine is antihistamine and mast cell stabilize that is used in eye drops for the treatment of allergic conjunctivitis.
Clinical Use Epinastine is a potent, long-acting H1 antihistamine and an inhibitor of the release of histamine and other transmitters from mast cells. It has some affinity for H2 receptors as well. It is used as an eye drop for allergic conjunctivitis. It does not penetrate into the CNS and is classified as a nonsedating antihistamine.

Technology Process of Epinastine

There total 23 articles about Epinastine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%