1,2-DIHYDROXYINDANE

Base Information

• Chemical Name: 1,2-DIHYDROXYINDANE
• CAS No.: 4370-02-9
• Molecular Formula: C9H10 O2
• Molecular Weight: 150.177
• Hs Code.: 2906299090
• Mol file: 4370-02-9.mol

Synonyms:1,2-Indandiol(6CI,7CI,8CI); Indene glycol

Chemical Property of 1,2-DIHYDROXYINDANE

Chemical Property:

• Vapor Pressure: 0.00108mmHg at 25°C
• Melting Point: 158 °C
• Boiling Point: 288.5°C at 760 mmHg
• PKA: 13.70±0.40(Predicted)
• Flash Point: 142.9°C
• PSA: 40.46000
• Density: 1.334g/cm³
• LogP: 0.63700
• Solubility.: soluble in Methanol

Purity/Quality:

98%,99%, ^*data from raw suppliers

1,2-Dihydroxyindane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2-DIHYDROXYINDANE

There total 149 articles about 1,2-DIHYDROXYINDANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

trans-2-bromo-1-indanol (10368-44-2,78684-69-2) + acetic anhydride (108-24-7) → cis-indane-1,2-diol (4370-02-9,4647-42-1,4647-43-2,67528-22-7,67528-23-8,71214-80-7,71214-82-9,78737-68-5)

Guidance literature:

trans-2-bromo-1-indanol; acetic anhydride; at 65 ℃; for 5h;

With sodium hydroxide; In water;

DOI:10.1016/S0957-4166(01)00006-4

Reference yield: 88.0%

cis-1,2-dihydroxyindane carbonate (19597-98-9,67131-50-4) → cis-indane-1,2-diol (4370-02-9,4647-42-1,4647-43-2,67528-22-7,67528-23-8,71214-80-7,71214-82-9,78737-68-5)

Guidance literature:

With water; sodium hydroxide; In methanol; at 20 ℃;

DOI:10.1002/anie.201406645

Reference yield: 87.0%

1-indene (95-13-6) → cis-indane-1,2-diol (4370-02-9,4647-42-1,4647-43-2,67528-22-7,67528-23-8,71214-80-7,71214-82-9,78737-68-5)

Guidance literature:

1-indene; With sodium periodate; acetic acid; lithium bromide; at 95 ℃; for 18h;

With potassium carbonate; In methanol; at 25 ℃; for 24h;

DOI:10.1021/ol052080n

upstream raw materials:

1-indene

cis-indane-1,2-diol

indan-2-ol

(1R,2S)-1,2-diacetoxyindane

Downstream raw materials:

2-indanone

2-(2-oxoethyl)benzaldehyde

cis-indane-1,2-diol

2-butyl-(3ar,8ac)-8,8a-dihydro-3aH-indeno[1,2-d][1,3,2]dioxaborole

Refernces

• 1、 Gutmann. "-". . p. 336,518, 646. Retrieved 1948.
• 2、 Batten,Miller. "-". . p. 3058. Retrieved 1974.
• 3、 Winstein,Roberts. "-". . p. 2297,2300. Retrieved 1953.
• 4、 Conceicao, Gelson J. Andrade,Moran, Paulo J. S.,Rodrigues, J. Augusto R.. "Homochiral (1S,2R)-1,2-indandiol from asymmetric reduction of 1,2-indanedione by resting cells of the yeast Trichosporon cutaneum". . p. 2327 - 2330. Retrieved 2003.
• 5、 Chung, Da Sol,Park, Steve H,Lee, Sang-Gi,Kim, Hyunwoo. "Electrochemically driven stereoselective approach tosyn-1,2-diol derivatives from vinylarenes and DMF". . p. 5892 - 5897. Retrieved 2021.
• 6、 Corti, Marco,Chiara, Rossella,Romani, Lidia,Mannucci, Barbara,Malavasi, Lorenzo,Quadrelli, Paolo. "g-C3N4/metal halide perovskite composites as photocatalysts for singlet oxygen generation processes for the preparation of various oxidized synthons". . p. 2292 - 2298. Retrieved 2021/04/12.