2-(2-fluoro-5-Methoxyphenyl)acetic acid

Base Information

• Chemical Name: 2-(2-fluoro-5-Methoxyphenyl)acetic acid
• CAS No.: 798563-50-5
• Molecular Formula: C9H9FO3
• Molecular Weight: 184.167
• Hs Code.: 2918990090
• Mol file: 798563-50-5.mol

Synonyms:2-(2-fluoro-5-Methoxyphenyl)acetic acid;(2-Fluoro-5-methoxyphenyl)acetic acid, 3-(Carboxymethyl)-4-fluoroanisole;2-Fluoro-5-methoxyphenylacetic acid 97%;2-Fluoro-5-methoxyphenylaceticacid97%

Chemical Property of 2-(2-fluoro-5-Methoxyphenyl)acetic acid

Chemical Property:

• Boiling Point: 317.3±27.0 °C(Predicted)
• PKA: 3.91±0.10(Predicted)
• PSA: 46.53000
• Density: 1.269±0.06 g/cm3(Predicted)
• LogP: 1.46140
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

2-Fluoro-5-methoxyphenylacetic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-fluoro-5-Methoxyphenyl)acetic acid

There total 4 articles about 2-(2-fluoro-5-Methoxyphenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

4-fluoro-3-methylanisol (2338-54-7) + sodium cyanide (143-33-9,25596-52-5) → 2-(2-fluoro-5-methoxyphenyl)acetic acid (798563-50-5)

Guidance literature:

4-fluoro-3-methylanisol; With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); In tetrachloromethane; for 1h; Heating / reflux;

sodium cyanide; In ethanol; water; for 2.5h; Heating / reflux;

With hydrogenchloride; sodium hydroxide; more than 3 stages;

Reference yield:

2-(2-fluoro-5-methoxyphenyl)acetonitrile (672931-28-1) → 2-(2-fluoro-5-methoxyphenyl)acetic acid (798563-50-5)

Guidance literature:

2-(2-fluoro-5-methoxyphenyl)acetonitrile; With sodium hydroxide; ethanol; water; at 80 ℃;

With hydrogenchloride; In water;

Reference yield:

2,2,2-trichloro-1-(2-fluoro-5-methoxyphenyl)ethanol (1418126-43-8) → 2-(2-fluoro-5-methoxyphenyl)acetic acid (798563-50-5)

Guidance literature:

With sodium tetrahydroborate; diphenyl diselenide; sodium hydroxide; In ethanol; at 20 - 40 ℃; Inert atmosphere;

DOI:10.1002/chem.201201895

upstream raw materials:

2-(2-fluoro-5-methoxyphenyl)acetonitrile

4-fluoro-3-methylanisol

sodium cyanide

2,2,2-trichloro-1-(2-fluoro-5-methoxyphenyl)ethanol

Downstream raw materials:

2-(2-fluoro-5-hydroxyphenyl)acetic acid

2-(5-(benzyloxy)-2-fluorophenyl)acetic acid

2-(5-(benzyloxy)-2-fluorophenyl)acetyl chloride

3-((6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-4-fluorophenol

Refernces

• 1、 -. "COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES AS GLUTAMINASE INHIBITORS FOR TREATING CANCERS THEREOF". Page/Page column 162. . Retrieved 2014/06/11.
• 2、 Resch, Verena,Lechner, Horst,Schrittwieser, Joerg H.,Wallner, Silvia,Gruber, Karl,MacHeroux, Peter,Kroutil, Wolfgang. "Inverting the regioselectivity of the berberine bridge enzyme by employing customized fluorine-containing substrates". supporting information. p. 13173 - 13179. Retrieved 2013/01/15.