2-(5-(benzyloxy)-2-fluorophenyl)acetyl chloride

Base Information

• Chemical Name: 2-(5-(benzyloxy)-2-fluorophenyl)acetyl chloride
• CAS No.: 1418126-44-9
• Molecular Formula: C₁₅H₁₂ClFO₂
• Molecular Weight: 278.71
• Mol file: 1418126-44-9.mol

Synonyms:

Chemical Property of 2-(5-(benzyloxy)-2-fluorophenyl)acetyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(5-(benzyloxy)-2-fluorophenyl)acetyl chloride

There total 5 articles about 2-(5-(benzyloxy)-2-fluorophenyl)acetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,2,2-trichloro-1-(2-fluoro-5-methoxyphenyl)ethanol (1418126-43-8) → 2-(5-(benzyloxy)-2-fluorophenyl)acetyl chloride (1418126-44-9)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydroxide; sodium tetrahydroborate; diphenyl diselenide / ethanol / 20 - 40 °C / Inert atmosphere

2: bromic acid / water / 5 h / 105 °C

3: sodium iodide; potassium hydroxide / ethanol / 20 °C

4: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 3 h / Inert atmosphere

With sodium tetrahydroborate; oxalyl dichloride; diphenyl diselenide; bromic acid; N,N-dimethyl-formamide; sodium iodide; potassium hydroxide; sodium hydroxide; In ethanol; water; toluene;

DOI:10.1002/chem.201201895

Reference yield:

2-fluoro-5-methoxybenzaldehyde (105728-90-3) → 2-(5-(benzyloxy)-2-fluorophenyl)acetyl chloride (1418126-44-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium hydroxide / methanol; N,N-dimethyl-formamide / 2 h / -10 °C / Inert atmosphere

1.2: 0.5 h / -10 °C / pH 1 / Inert atmosphere

2.1: sodium hydroxide; sodium tetrahydroborate; diphenyl diselenide / ethanol / 20 - 40 °C / Inert atmosphere

3.1: bromic acid / water / 5 h / 105 °C

4.1: sodium iodide; potassium hydroxide / ethanol / 20 °C

5.1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 3 h / Inert atmosphere

With sodium tetrahydroborate; oxalyl dichloride; diphenyl diselenide; bromic acid; N,N-dimethyl-formamide; sodium iodide; potassium hydroxide; sodium hydroxide; In methanol; ethanol; water; N,N-dimethyl-formamide; toluene;

DOI:10.1002/chem.201201895

Reference yield:

2-(2-fluoro-5-methoxyphenyl)acetic acid (798563-50-5) → 2-(5-(benzyloxy)-2-fluorophenyl)acetyl chloride (1418126-44-9)

Guidance literature:

Multi-step reaction with 3 steps

1: bromic acid / water / 5 h / 105 °C

2: sodium iodide; potassium hydroxide / ethanol / 20 °C

3: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 3 h / Inert atmosphere

With oxalyl dichloride; bromic acid; N,N-dimethyl-formamide; sodium iodide; potassium hydroxide; In ethanol; water; toluene;

DOI:10.1002/chem.201201895

upstream raw materials:

2,2,2-trichloro-1-(2-fluoro-5-methoxyphenyl)ethanol

2-fluoro-5-methoxybenzaldehyde

2-(2-fluoro-5-methoxyphenyl)acetic acid

2-(2-fluoro-5-hydroxyphenyl)acetic acid

Downstream raw materials:

2-(5-(benzyloxy)-2-fluorophenyl)-N-(3,4-dimethoxyphenethyl)-N-methylacetamide

3-((6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl)-4-fluorophenol

1-(5-(benzyloxy)-2-fluorobenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline

C₁₉H₂₂FNO₃

Refernces