PIPERIDIN-4-YLMETHYL-CARBAMIC ACID BENZYL ESTER-HCL

Base Information

• Chemical Name: PIPERIDIN-4-YLMETHYL-CARBAMIC ACID BENZYL ESTER-HCL
• CAS No.: 155456-34-1
• Molecular Formula: C14H21ClN2O2
• Molecular Weight: 284.78174
• Hs Code.: 2933399090
• Mol file: 155456-34-1.mol

Synonyms:PIPERIDIN-4-YLMETHYL-CARBAMIC ACID BENZYL ESTER-HCL;CarbaMic acid, (4-piperidinylMethyl)-, phenylMethyl ester, Monohydrochloride;4-(CBZ-AMINOMETHYL)-PIPERIDINE HCL;Benzyl (piperidin-4-ylmethyl)

Chemical Property of PIPERIDIN-4-YLMETHYL-CARBAMIC ACID BENZYL ESTER-HCL

Chemical Property:

• PSA: 53.85000
• LogP: 3.24760
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Benzyl(piperidin-4-ylmethyl)carbamatehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of PIPERIDIN-4-YLMETHYL-CARBAMIC ACID BENZYL ESTER-HCL

There total 5 articles about PIPERIDIN-4-YLMETHYL-CARBAMIC ACID BENZYL ESTER-HCL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(Benzyloxycarbonylamino-methyl)-piperidine-1-carboxylic acid tert-butyl ester (155456-33-0) → benzyl (piperidin-4-ylmethyl)carbamate hydrochloride (155456-34-1)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane;

Reference yield:

4-Aminomethylpiperidine (7144-05-0) → benzyl (piperidin-4-ylmethyl)carbamate hydrochloride (155456-34-1)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrahydrofuran

2: sodium carbonate / ethyl acetate

3: hydrogenchloride / 1,4-dioxane

With hydrogenchloride; sodium carbonate; In tetrahydrofuran; 1,4-dioxane; ethyl acetate;

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → benzyl (piperidin-4-ylmethyl)carbamate hydrochloride (155456-34-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate / ethyl acetate

2: hydrogenchloride / 1,4-dioxane

With hydrogenchloride; sodium carbonate; In 1,4-dioxane; ethyl acetate;

upstream raw materials:

4-(Benzyloxycarbonylamino-methyl)-piperidine-1-carboxylic acid tert-butyl ester

4-Aminomethylpiperidine

benzyl chloroformate

tert-butyl 4-(aminomethyl)piperidine-1-carboxylate

Downstream raw materials:

C₃₇H₄₉N₅O₅

Refernces

• 1、 -. "N-substituted nonaryl-heterocyclic NMDA/NR2B antagonists". . . Retrieved 2019/08/08.