3,5-Diphenyl-2-forMylpyrrole

Base Information

• Chemical Name: 3,5-Diphenyl-2-forMylpyrrole
• CAS No.: 40872-77-3
• Molecular Formula: C17H13NO
• Molecular Weight: 247.296
• Mol file: 40872-77-3.mol

Synonyms:3,5-Diphenyl-2-forMylpyrrole;3,5-diphenyl-1H-Pyrrole-2-carboxaldehyde

Chemical Property of 3,5-Diphenyl-2-forMylpyrrole

Chemical Property:

• Boiling Point: 473.2±45.0 °C(Predicted)
• PKA: 14.90±0.50(Predicted)
• PSA: 0.00000
• Density: 1.177±0.06 g/cm3(Predicted)
• LogP: 0.00000

Purity/Quality:

>98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-Diphenyl-2-forMylpyrrole

There total 14 articles about 3,5-Diphenyl-2-forMylpyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.5%

2,4-diphenylpyrrole (3274-56-4) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 3,5-diphenyl-1H-pyrrole-2-carbaldehyde (40872-77-3)

Guidance literature:

With trichlorophosphate; at 10 - 20 ℃; for 1.5h; Cooling;

DOI:10.1134/S0036023614100027

Reference yield: 66.6%

3,5-diphenyl-1H-pyrrole-2-carbonitrile (131475-18-8) → 3,5-diphenyl-1H-pyrrole-2-carbaldehyde (40872-77-3)

Guidance literature:

With diisobutylaluminium hydride; In hexane; dichloromethane; at -78 - 20 ℃; Schlenk technique; Inert atmosphere;

DOI:10.1002/ejoc.201700773

Reference yield: 62.0%

N-methoxy-N-methyl-3,5-diphenyl-1H-pyrrole-2-carboxamide → 3,5-diphenyl-1H-pyrrole-2-carbaldehyde (40872-77-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at -78 - 20 ℃; Schlenk technique; Inert atmosphere;

DOI:10.1002/ejoc.201700773

upstream raw materials:

2,4-diphenylpyrrole

N-methyl-N-phenylformamide

3,5-diphenyl-3,4-dihydro-2H-pyrrole

4-nitro-1,3-diphenyl-butan-1-one

Downstream raw materials:

(3,5-diphenyl-pyrrol-2-yl)-methanol

Refernces

• 1、 Sun, Jiaqiong,Zheng, Guangfan,Fu, Yongmei,Wang, Lihong,Li, Yan,Zhang, Qian. "Copper-Catalyzed Cascade Aminoalkynylation-Oxidation of Propargylic Alcohols: Stereospecific Synthesis of (Z)-2-Amino Conjugated Enynals/Enynones". . p. 5597 - 5600. Retrieved 2018/09/12.
• 2、 Antina,Berezin,Dudina,Burkova,Nikonova, A. Yu.. "Synthesis, spectral-luminescent properties of B(III) and Zn(II) complexes with alkyl- and aryl-substituted dipyrrins and azadipyrrins". . p. 1187 - 1194. Retrieved 2015/02/02.