2-CHLORO-2,2-DIFLUOROACETOPHENONE

Base Information

• Chemical Name: 2-CHLORO-2,2-DIFLUOROACETOPHENONE
• CAS No.: 384-67-8
• Molecular Formula: C8H5ClF2O
• Molecular Weight: 190.577
• Hs Code.: 29147000
• Mol file: 384-67-8.mol

Synonyms:Acetophenone, 2-chloro-2,2-difluoro- (6CI,7CI,8CI);Chlorodifluoromethyl phenyl ketone;NSC 42611;

Chemical Property of 2-CHLORO-2,2-DIFLUOROACETOPHENONE

Chemical Property:

• Vapor Pressure: 1.01E-05mmHg at 25°C
• Melting Point: 102-103 °C
• Refractive Index: n20/D 1.497(lit.)
• Boiling Point: 199.1 °C at 760 mmHg
• Flash Point: 74.2 °C
• PSA: 17.07000
• Density: 1.33 g/cm³
• LogP: 2.70090
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility.: Difficult to mix.

Purity/Quality:

99% ^*data from raw suppliers

2-Chloro-2,2-difluoroacetophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Chloro-2,2-difluoroacetophenone can be used:As a reagent in the difluoromethylation of various phenols to yield aryl difluoromethyl ethers.As a precursor in the Baylis-Hillman reaction of fluoroalkyl ketones to obtain chlorodifluoromethyl containing products.As a substrate in the synthesis of propargyl alcohols using a novel ruthenium catalyst.

Technology Process of 2-CHLORO-2,2-DIFLUOROACETOPHENONE

There total 17 articles about 2-CHLORO-2,2-DIFLUOROACETOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2,2-difluoro-1-phenyl-1-trimethylsiloxyethene (86340-78-5) → 2-chloro-2,2-difluoroacetophenone (384-67-8)

Guidance literature:

With chlorine; In dichloromethane; at -78 ℃; for 0.5h;

DOI:10.1021/jo061799l

Reference yield: 87.0%

phenylmagnesium bromide (100-58-3) + 2-chloro-2,2-difluoroacetic acid (76-04-0) → 2-chloro-2,2-difluoroacetophenone (384-67-8)

Guidance literature:

With sodium hydroxide;

DOI:10.1002/anie.199716231

Reference yield: 84.0%

2-chloro-2,2-difluoroacetic acid (76-04-0) → 2-chloro-2,2-difluoroacetophenone (384-67-8)

Guidance literature:

DOI:10.1246/bcsj.63.428

upstream raw materials:

phenyllithium

2-chloro-2,2-difluoroacetic acid

fluorosulfonyldifluoroacetyl fluoride

benzene

Downstream raw materials:

2-chloro-2,2-difluoro-1-phenyl-ethan-1-ol

α,α,β-trichloro-β,β-difluoroethylbenzene

<1.1.3.3.-Tetrafluor-1.3-dichlor-2-hydroxy-2-propyl>-benzol

α-chloro-β,β-difluorostyrene

Refernces

• 1、 Van Hende, Eva,Verniest, Guido,Surmont, Riccardo,De Kimpe, Norbert. "Synthesis of 3-substituted 2-fluoro- And 2,2-difluoroaziridines". . p. 2935 - 2937. Retrieved 2008/02/07.
• 2、 Weber,Brinker. "Evidence for a stepwise addition of carbenes to strained double bonds: Reactions of dihalocarbenes with cyclopropenes". . p. 1623 - 1626. Retrieved 2007/10/03.