76-04-0Relevant articles and documents
Synthesis production process of difluorochloroacetic acid
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Paragraph 0015-0021, (2017/05/10)
The invention discloses a synthesis production process of difluorochloroacetic acid, comprising the following steps: charging sulfur trioxide with nitrogen gas into an oxidation reaction kettle by an intermittent process, starting stirring; after reaching a certain temperature, adding difluorotetrachloroethane and catalyst according to a predetermined ratio into the oxidation reaction kettle; heating for reaction, observing the backflow condition, starting steaming the byproduct sulfuric chloride when the kettle temperature rises to a certain temperature while the backflow is small; after steaming the byproduct sulfuric chloride, carrying out charging for the second time; carrying out three-stage spray hydrolysis and absorption on the product difluorochloracetyl chloride to generate crude product difluorochloroacetic acid, and carrying out defluorination and rectification on the crude product to obtain finished product difluorochloroacetic acid. The synthesis production process of difluorochloroacetic acid disclosed by the invention adopts the difluorotetrachloroethane as a raw material, the finished product difluorochloroacetic acid is prepared by oxidation reaction, the preparation process has reasonable design, high absorption rate, high overall yield and low energy consumption; and the byproduct can be hydrolyzed and reused, so that the production process is clean, environment-friendly, safe and reliable.
Preparation and properties of two novel selenoacetic acids: HCF 2C(O)SeH and ClCF2C(O)SeH
Gomez Castano, Jovanny A.,Romano, Rosana M.,Beckers, Helmut,Willner, Helge,Della Vedova, Carlos O.
body text, p. 2608 - 2615 (2012/05/04)
The novel selenocarboxylic Se-acids, HCF2C(O)SeH and ClCF 2C(O)SeH, were prepared by treating the corresponding carboxylic acids with Woollins' reagent. The boiling points were extrapolated from the vapor pressure curves to be 364 and 359 K for HCF2C(O)SeH and ClCF2C(O)SeH, respectively. Both compounds are unstable at ambient temperatures and decompose to the corresponding seleno anhydrides and release of H2Se. Hydrolysis results in formation of the carboxylic acids and hydrogen selenide, while diselenides presumably are obtained by oxidation. The conformational properties of these acids were studied by vibrational spectroscopy in combination with ab initio and DFT methods. IR vapor-phase spectra, Raman spectra of the neat liquids, and IR spectra of the Ar-matrix-isolated compounds deposited at two different nozzle temperatures were interpreted in terms of quenching conformational equilibria. The most stable structure of both acids was found to be syn-gauche in equilibrium with a second anti-syn form in HCF2C(O)SeH and with another two conformers, anti-gauche and anti-syn, in ClCF2C(O)SeH.
Preparation of compounds comprising a CHF2 or CHF group
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Page/Page column 2; 3, (2008/06/13)
Producing compounds (I) with a mono- or difluoromethyl group from compounds (II) with a mono- or difluorohalomethyl group, where halo is bromo, iodo or preferably chloro, comprises reacting (II) with zinc in the presence of an alcohol. An independent claim is also included for an azeotropic mixture of methyl difluoroacetate and methanol.