CC 5013 hydrochloride

Base Information

• Chemical Name: CC 5013 hydrochloride
• CAS No.: 1243329-97-6
• Molecular Formula: C₁₃H₁₃N₃O₃*ClH
• Molecular Weight: 295.725
• Mol file: 1243329-97-6.mol

Synonyms:(RS)-3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione hydrochloride

Chemical Property of CC 5013 hydrochloride

Chemical Property:

• Solubility.: insoluble in H2O; ≥1.83 mg/mL in EtOH; ≥72.2 mg/mL in DMSO

Purity/Quality:

>98% ^*data from raw suppliers

LenalidomideHCl ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of CC 5013 hydrochloride

There total 7 articles about CC 5013 hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.5%

3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione (827026-45-9) → (RS)-3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione hydrochloride (1243329-97-6)

Guidance literature:

3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione; With hydrogen; palladium 10% on activated carbon; In methanol; at 21 - 35 ℃; for 18h; under 2400.24 Torr;

With hydrogenchloride; In water;

Reference yield:

Lenalidomide (879126-98-4,879126-99-5,191732-72-6) → (RS)-3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione hydrochloride (1243329-97-6)

Guidance literature:

With hydrogenchloride; In ethanol; water; at 20 ℃; Product distribution / selectivity; Heating;

Reference yield:

rac-α-aminoglutarimide hydrochloride (24666-56-6,2686-86-4) → (RS)-3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)piperidine-2,6-dione hydrochloride (1243329-97-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetonitrile / 0.25 h / 20 °C

1.2: 7 h / 20 °C / Reflux

2.1: hydrogen / palladium 10% on activated carbon / methanol / 18 h / 21 - 35 °C / 2400.24 Torr

With hydrogen; palladium 10% on activated carbon; In methanol; acetonitrile;

upstream raw materials:

Lenalidomide

3-(4-nitro-1-oxoisoindolin-2-yl)piperidine-2,6-dione

rac-α-aminoglutarimide hydrochloride

2-methyl-3-nitro-benzoic acid methyl ester

Downstream raw materials:

Lenalidomide

Refernces

• 1、 -. "ACID ADDITION SALTS OF LENALIDOMIDE". Page/Page column 32. . Retrieved 2011/05/11.