Lormetazepam

Base Information Edit

Chemical Name:Lormetazepam
CAS No.:848-75-9
Molecular Formula:C16H12 Cl2 N2 O2
Molecular Weight:335.189
Hs Code.:
European Community (EC) Number:212-700-5
UNII:GU56C842ZA
DSSTox Substance ID:DTXSID40862442
Nikkaji Number:J7.142K
Wikipedia:Lormetazepam
Wikidata:Q186257
NCI Thesaurus Code:C87673
Metabolomics Workbench ID:49626
ChEMBL ID:CHEMBL22097
Mol file:848-75-9.mol

Synonyms:lormetazepam;methyllorazepam

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Lormetazepam Edit

Chemical Property:

Vapor Pressure:4.23E-14mmHg at 25°C
Melting Point:163-168ºC
Refractive Index:1.6100 (estimate)
Boiling Point:575.8ºC at 760mmHg
PKA:11.60±0.40(Predicted)
Flash Point:302.1ºC
PSA：52.90000
Density:1.44 g/cm3
LogP:2.62620
Storage Temp.:Controlled Substance, -20?C Freezer
XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:334.0275830
Heavy Atom Count:22
Complexity:471

Purity/Quality:

Safty Information:

Pictogram(s): F,T
Hazard Codes:F,T
Statements: 11-23/24/25-39/23/24/25-22
Safety Statements: 7-16-36/37-45-36

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C2=C(C=C(C=C2)Cl)C(=NC(C1=O)O)C3=CC=CC=C3Cl
Recent ClinicalTrials:Comparison of Lormetazepam and Midazolam Used as Sedatives for Patients That Require Intensive Care
Recent EU Clinical Trials:Self-help program for hypnotics withdrawal in insomniac patients: A randomized controlled clinical trial.
Recent NIPH Clinical Trials:The Effects of Benzodiazepine and Orexin Receptor Antagonist on Cognitive Function Revealed by Auditory Event-related Potentials
Uses An analog of Lorazepam (L469850). Sedative, hypnotic. Controlled substance (depressant).
Clinical Use #N/A
Drug interactions Potentially hazardous interactions with other drugs Antibacterials: metabolism possibly increased by rifampicin. Antipsychotics: increased sedative effects; risk of serious adverse effects in combination with clozapine. Antivirals: concentration possibly increased by ritonavir. Disulfiram: metabolism inhibited, increased sedative effects. Sodium oxybate: enhanced effect - avoid.

Technology Process of Lormetazepam

There total 3 articles about Lormetazepam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: