Lorazepam

Base Information Edit

Chemical Name:Lorazepam
CAS No.:846-49-1
Molecular Formula:C15H10Cl2N2O2
Molecular Weight:321.163
Hs Code.:2933910000
European Community (EC) Number:212-687-6
NSC Number:289758
UNII:O26FZP769L
DSSTox Substance ID:DTXSID7023225
Nikkaji Number:J3.337E
Wikipedia:Lorazepam
Wikidata:Q408265
NCI Thesaurus Code:C619
RXCUI:6470
Pharos Ligand ID:1WCX3CYLHHPH
Metabolomics Workbench ID:42594
ChEMBL ID:CHEMBL580
Mol file:846-49-1.mol

Synonyms:Apo Lorazepam;Apo-Lorazepam;Ativan;Donix;Duralozam;Durazolam;Idalprem;Laubeel;lorazep von ct;Lorazepam;Lorazepam Medical;Lorazepam neuraxpharm;Lorazepam ratiopharm;Lorazepam-neuraxpharm;Lorazepam-ratiopharm;Medical, Lorazepam;Novo Lorazem;Novo-Lorazem;Nu Loraz;Nu-Loraz;Orfidal Wyeth;Sedicepan;Sinestron;Somagerol;Témesta;Temesta;Tolid;Von Ct, Lorazep;WY 4036;WY-4036;WY4036;Wyeth, Orfidal

This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Lorazepam Edit

Chemical Property:

Appearance/Colour:White crystalline solid
Melting Point:166-168 °C
Refractive Index:1.6070 (estimate)
Boiling Point:533.8 °C at 760 mmHg
PKA:pK1 1.3; pK2 11.5(at 25℃)
Flash Point:276.7 °C
PSA：61.69000
Density:1.52 g/cm³
LogP:2.67490
Storage Temp.:−20°C
Solubility.:Practically insoluble in water, sparingly soluble in ethanol (96 per cent), sparingly soluble or slightly soluble in methylene chloride.
Water Solubility.:54mg/L(temperature not stated)
XLogP3:2.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:320.0119330
Heavy Atom Count:21
Complexity:443

Purity/Quality:

Safty Information:

Pictogram(s): Xn,T,F
Hazard Codes:Xn,T,F
Statements: 63-39/23/24/25-23/24/25-11-36-20/21/22
Safety Statements: 36/37-45-16

MSDS Files:: SDS file from LookChem

Useful:

Drug Classes:Benzodiazepines, Antianxiety Agents
Canonical SMILES:C1=CC=C(C(=C1)C2=NC(C(=O)NC3=C2C=C(C=C3)Cl)O)Cl
Recent ClinicalTrials:Lorazepam Sedation for Critically Ill Children
Recent EU Clinical Trials:Reducing pain and discomfort during and after bone marrow aspiration
Recent NIPH Clinical Trials:Study about the efficacy of lorazepam as a premedication for the disabled patients showing serious maladaptive behaviors in dentistry
Uses An anxiolytic, and anticonvulsant. Controlled substance (depressant)
Therapeutic Function Tranquilizer

Technology Process of Lorazepam

There total 12 articles about Lorazepam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%