6-Methyl-2-pyridinecarboxylic acid

Base Information

• Chemical Name: 6-Methyl-2-pyridinecarboxylic acid
• CAS No.: 934-60-1
• Molecular Formula: C7H7NO2
• Molecular Weight: 137.138
• Hs Code.: 29333990
• European Community (EC) Number: 213-287-4
• NSC Number: 26023
• UNII: KB675Y352L
• DSSTox Substance ID: DTXSID20239416
• Nikkaji Number: J101.238J
• Wikidata: Q27282160
• ChEMBL ID: CHEMBL1650458
• Mol file: 934-60-1.mol

Synonyms:934-60-1;6-Methyl-2-pyridinecarboxylic acid;6-Methylpicolinic acid;6-Methylpyridine-2-carboxylic acid;6-methyl-2-picolinic acid;2-Pyridinecarboxylic acid, 6-methyl-;Picolinic acid, 6-methyl-;2-Carboxy-6-methylpyridine;2-Picoline-6-carboxylic acid;6-methyl-2-picolinicacid;6-methyl picolinic acid;6-methyl-picolinic acid;MFCD00023481;UNII-KB675Y352L;KB675Y352L;EINECS 213-287-4;NSC 26023;NSC-26023;6-Methyl-2-pyridinecarboxylicacid;6-Methyl-pyridine-2-carboxylic acid;2-METHYL-6-PYRIDINECARBOXYLIC ACID;SCHEMBL118409;CHEMBL1650458;LTUUGSGSUZRPRV-UHFFFAOYSA-;DTXSID20239416;6-methyl-2-pyridylcarboxylic acid;6 -methyl-2-pyridylcarboxylic acid;NSC26023;BBL023748;CL0233;GEO-01924;STL362881;2-Carboxylic Acid-6-Methyl Pyridine;AKOS005255224;AB01368;AC-7509;CS-W002139;FG-0452;SY004175;AM20070251;BB 0260758;FT-0633141;M0873;EN300-28863;AO-801/41077373;W-100242;Q27282160;Z278017928

Chemical Property of 6-Methyl-2-pyridinecarboxylic acid

Chemical Property:

• Appearance/Colour: White to beige powder
• Vapor Pressure: 0.00148mmHg at 25°C
• Melting Point: 130 °C
• Refractive Index: 1.561
• Boiling Point: 283.6 °C at 760 mmHg
• PKA: pK1:5.83 (25°C)
• Flash Point: 125.3 °C
• PSA: 50.19000
• Density: 1.23 g/cm³
• LogP: 1.08820
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Water Solubility.: Soluble in water
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 137.047678466
• Heavy Atom Count: 10
• Complexity: 136

Purity/Quality:

99% ^*data from raw suppliers

6-Methyl-2-pyridinecarboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1=NC(=CC=C1)C(=O)O
• Uses: Pharmacological activity studied in regard to: Interactions of carrier ligands of antidiabetic metal complexes with human serum albuminAbility to chelate metalloenzyme inhibitorsInteractions of insulin-mimetic zinc(II) complexes with cell constituentsReactant for: Synthesis of inhibitors of human 11β -hydroxysteroid dehydrogenase type 1Lewis base organocatalysts for stereoselective hydrosilylation reactionsBiological studies of insulin-enhancing complexes

Technology Process of 6-Methyl-2-pyridinecarboxylic acid

There total 16 articles about 6-Methyl-2-pyridinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.9%

2-(Hydroxymethyl)-6-methylpyridine (1122-71-0) → 6-methyl-2-pyridinecarboxaldehyde (1122-72-1) + 6-methyl-2-pyridinecarboxylic acid (934-60-1)

Guidance literature:

With sodium hypochlorite; C₈H₁₈NPol; sodium hydrogencarbonate; In water; toluene; at 15 - 20 ℃; for 4.5h; Product distribution / selectivity;

Reference yield: 84.0%

2-(bromomethyl)-6-methylpyridine (68470-59-7) → 6-methyl-2-pyridinecarboxylic acid (934-60-1)

Guidance literature:

With 5,10,15,20-tetra(4-nitrophenyl) porphyrinato iron chloride; [bis(acetoxy)iodo]benzene; water; In methanol; at 50 ℃; for 12h;

DOI:10.1016/j.bmcl.2010.07.071

Reference yield: 75.0%

2,6-dimethylpyridine (108-48-5) → 6-methyl-2-pyridinecarboxylic acid (934-60-1)

Guidance literature:

With potassium permanganate; In water-d2; at 20 - 60 ℃; for 5h;

upstream raw materials:

2,6-dimethylpyridine

6-methyl-2-pyridinecarboxaldehyde

2-(6-methylpyridin-2-yl)-ethanol

3-methylbenzene-1,2-diol

Downstream raw materials:

ethyl 6-methylpyridine-2-carboxylate

(4-Methoxy-phenyl)-(6-methyl-[2]pyridyl)-methanol

6-methyl-1-oxy-pyridine-2-carboxylic acid

6-methyl-pyridine-2-carbonyl chloride

Refernces

• 1、 Ma, Cong,Zhao, Chuan-Qi,Xu, Xue-Tao,Li, Zhao-Ming,Wang, Xiang-Yang,Zhang, Kun,Mei, Tian-Sheng. "Nickel-catalyzed carboxylation of aryl and heteroaryl fluorosulfates using carbon dioxide". . p. 2464 - 2467. Retrieved 2019/04/10.
• 2、 Zhong, Qi-Di,Xue, Yun-Zhou,Yan, Hong,Song, Xiu-Qing,Zhong, Ru-Gang. "Preparation of 4,7-diphenyl-1,10-phenanthroline-2,9-dicarboxylic acid catalyzed by iron(III)porphyrins with (diacetoxyiodo)benzene". body text. p. 5532 - 5535. Retrieved 2010/12/20.