C₇H₆⁽²⁾HNO₃

Base Information

• Chemical Name: C₇H₆⁽²⁾HNO₃
• CAS No.: 92241-90-2
• Molecular Formula: C₇H₇NO₃
• Molecular Weight: 154.13
• Mol file: 92241-90-2.mol

Synonyms:C₇H₆⁽²⁾HNO₃

Chemical Property of C₇H₆⁽²⁾HNO₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of C₇H₆⁽²⁾HNO₃

There total 3 articles about C₇H₆⁽²⁾HNO₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methoxy-4-nitrobenzoic acid (5081-36-7) → C7H6(2)HNO3 (92241-90-2)

Guidance literature:

Multi-step reaction with 4 steps

1: thionyl chloride

3: 13 g / 85 °C / Hofmann rearrangement

4: 1.) boron trifluoride etherate, tert-butyl nitrite / 1.) CH₂Cl₂

With thionyl chloride; tert.-butylnitrite; boron trifluoride diethyl etherate;

DOI:10.1021/ja00335a035

Reference yield:

3-methoxy-4-nitrobenzoic acid chloride (67579-92-4) → C7H6(2)HNO3 (92241-90-2)

Guidance literature:

Multi-step reaction with 3 steps

2: 13 g / 85 °C / Hofmann rearrangement

3: 1.) boron trifluoride etherate, tert-butyl nitrite / 1.) CH₂Cl₂

With tert.-butylnitrite; boron trifluoride diethyl etherate;

DOI:10.1021/ja00335a035

Reference yield:

3-methoxy-4-nitrobenzamide (92241-87-7) → C7H6(2)HNO3 (92241-90-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 13 g / 85 °C / Hofmann rearrangement

2: 1.) boron trifluoride etherate, tert-butyl nitrite / 1.) CH₂Cl₂

With tert.-butylnitrite; boron trifluoride diethyl etherate;

DOI:10.1021/ja00335a035

upstream raw materials:

3-methoxy-4-nitrobenzoic acid

3-methoxy-4-nitrobenzoic acid chloride

3-methoxy-4-nitrobenzamide

Downstream raw materials:

2-methoxy-4-deuterioaniline

Refernces