5-amino-3-(4-methoxy-benzyl)-isoxazole-4-carboxylic acid amide

Base Information

• Chemical Name: 5-amino-3-(4-methoxy-benzyl)-isoxazole-4-carboxylic acid amide
• CAS No.: 1019971-80-2
• Molecular Formula: C₁₂H₁₃N₃O₃
• Molecular Weight: 247.254
• Mol file: 1019971-80-2.mol

Synonyms:5-amino-3-(4-methoxy-benzyl)-isoxazole-4-carboxylic acid amide

Chemical Property of 5-amino-3-(4-methoxy-benzyl)-isoxazole-4-carboxylic acid amide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 5-amino-3-(4-methoxy-benzyl)-isoxazole-4-carboxylic acid amide

There total 1 articles about 5-amino-3-(4-methoxy-benzyl)-isoxazole-4-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

4-methoxyphenylacetohydroximoyl chloride + cyanoacetic acid amide (107-91-5) → 5-amino-3-(4-methoxy-benzyl)-isoxazole-4-carboxylic acid amide (1019971-80-2)

Guidance literature:

cyanoacetic acid amide; With sodium ethanolate; In tetrahydrofuran; ethanol; at 20 ℃;

4-methoxyphenylacetohydroximoyl chloride; In tetrahydrofuran; ethanol; at 0 - 45 ℃; for 2h; Further stages.;

DOI:10.1021/jm701372r

Reference yield: 13.0%

C12H17NO3 (832684-43-2) + 5-amino-3-(4-methoxy-benzyl)-isoxazole-4-carboxylic acid amide (1019971-80-2) → C24H28N4O5 (1019971-65-3)

Guidance literature:

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 12h;

DOI:10.1021/jm701372r

upstream raw materials:

cyanoacetic acid amide

Downstream raw materials:

C₂₄H₂₈N₄O₅

Refernces