1-benzotriazoleacetyl chloride

Base Information

• Chemical Name: 1-benzotriazoleacetyl chloride
• CAS No.: 158502-20-6
• Molecular Formula: C₈H₆ClN₃O
• Molecular Weight: 195.608
• Mol file: 158502-20-6.mol

Synonyms:1-benzotriazoleacetyl chloride

Chemical Property of 1-benzotriazoleacetyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1-benzotriazoleacetyl chloride

There total 1 articles about 1-benzotriazoleacetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-(1H-1,2,3-benzotriazol-1-yl)acetic acid (4144-64-3) → 1-benzotriazoleacetyl chloride (158502-20-6)

Guidance literature:

With thionyl chloride; In acetone; benzene; for 8h; Heating;

Reference yield:

[(2-methoxybenzyl)amino](4-methylphenyl)acetic acid + 1-benzotriazoleacetyl chloride (158502-20-6) → [(1H-benzotriazol-1-ylacetyl)(2-methoxybenzyl)amino](4-methylphenyl)acetic acid

Guidance literature:

With dmap; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

Reference yield:

[(2-methoxybenzyl)amino](4-methylphenyl)acetic acid + 1-benzotriazoleacetyl chloride (158502-20-6) → 2-(1H-benzotriazol-1-yl)-N-(2-methoxybenzyl)-N-{1-(4-methylphenyl)-2-oxo-2-[(tetrahydrofuran-2-ylmethyl)amino]ethyl}acetamide

Guidance literature:

Multi-step reaction with 2 steps

1.1: dmap / N,N-dimethyl-formamide / 1 h / 20 °C

2.1: 1-chloro-1-(dimethylamino)-2-methyl-1-propene / dichloromethane / 1 h / 20 °C

2.2: 20 °C

With dmap; 1-chloro-1-(dimethylamino)-2-methyl-1-propene; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

2-(1H-1,2,3-benzotriazol-1-yl)acetic acid

Refernces

• 1、 Halwe, Kirti,Srivastava, S. K.. "Synthesis of some New Pharmacophores derived from Imidazole and Benzimidazole". . p. 59 - 62. Retrieved 2007/10/03.
• 2、 Jain, Jyoti,Srivastava, Santosh K.. "Synthesis of Novel N-Substituted Phenothiazines and Piperazines as Potential Biologically Active Agents". . p. 691 - 692. Retrieved 2007/10/03.