{[2-Hydroxy-1,1-bis(hydroxymethyl)ethyl]ammonio}acetate

Base Information

• Chemical Name: {[2-Hydroxy-1,1-bis(hydroxymethyl)ethyl]ammonio}acetate
• CAS No.: 5704-04-1
• Molecular Formula: C6H13NO5
• Molecular Weight: 179.173
• Hs Code.: 29052900
• Mol file: 5704-04-1.mol

Synonyms:CHEBI:46759;{[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]ammonio}acetate;SCHEMBL42019;N-tris(hydroxymethyl)methylammonioacetate;N-[tris(hydroxymethyl)methyl]glycine or N-(2-hydroxy-1,1-bis[hydroxymethyl]ethyl)glycine

Chemical Property of {[2-Hydroxy-1,1-bis(hydroxymethyl)ethyl]ammonio}acetate

Chemical Property:

• Appearance/Colour: White/clear crystalline powder
• Vapor Pressure: 3.92E-12mmHg at 25°C
• Melting Point: 186-188 °C (dec.)
• Refractive Index: 1.553
• Boiling Point: 500.9 °C at 760 mmHg
• PKA: 8.1(at 25℃)
• Flash Point: 256.7 °C
• PSA: 110.02000
• Density: 1.449 g/cm³
• LogP: -2.23280
• Storage Temp.: Store at RT.
• Solubility.: H2O: 4 M at 20 °C, clear, colorless
• Water Solubility.: soluble
• XLogP3: -4.4
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 179.07937252
• Heavy Atom Count: 12
• Complexity: 131

Purity/Quality:

99%-101% ^*data from raw suppliers

Tricine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36-36/37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C(C(=O)[O-])[NH2+]C(CO)(CO)CO
• Uses: Good's buffers Tricine is used as an electrophoresis buffer and involved in the separation of low molecular weight proteins and peptides. It operates in the pH range between 7.4 and 8.8. It acts as an effective scavenger of hydroxyl radicals during the study of radiation-induced membrane damage. It is also used in resuspension of cell pellets.A zwitterionic buffer useful in the pH range of 7.4-8.8. Has a pKa 8.05 at 25°C.A zwitterionic amino acid commonly useful in the pH range of 7.4-8.8. Has a pKa 8.05 at 25°C. Tricine is a commonly used electrophoresis buffer. Trizma? Buffer substance has been used as an eluent in asymmetrical flow field-flow fractionation (AFFFF).

Technology Process of {[2-Hydroxy-1,1-bis(hydroxymethyl)ethyl]ammonio}acetate

There total 8 articles about {[2-Hydroxy-1,1-bis(hydroxymethyl)ethyl]ammonio}acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ N-[tris(hydroxymethyl)methyl]glycine (5704-04-1)

Guidance literature:

Chloressigsaeure (Na-Salz), Tri(hydroxymethyl)aminoethan;

Reference yield:

2-amino-2-hydroxymethyl-1,3-propanediol (77-86-1) + 2-chloro-ethanol (107-07-3) → N-[tris(hydroxymethyl)methyl]glycine (5704-04-1)

Guidance literature:

2-amino-2-hydroxymethyl-1,3-propanediol; 2-chloro-ethanol; In ethanol; at 60 ℃; for 4h; under 0 Torr;

With dihydrogen peroxide; In ethanol; at 65 ℃; for 6h; under 0 Torr;

Reference yield:

glycolamide (598-42-5) + 2-amino-2-hydroxymethyl-1,3-propanediol (77-86-1) → N-[tris(hydroxymethyl)methyl]glycine (5704-04-1)

Guidance literature:

glycolamide; 2-amino-2-hydroxymethyl-1,3-propanediol; In methanol; at 60 ℃; for 4h; under 75.0075 Torr;

With water; In methanol; at 94 ℃; for 6h; under 112.511 Torr;

upstream raw materials:

sodium 2-bromoacetate

2-amino-2-hydroxymethyl-1,3-propanediol

chloroacetic acid ethyl ester

sodium cyanide

Refernces

• 1、 -. "Stabilizing labeled antibody using amino acids". . . Retrieved 2011/11/07.