diethyl 2-[boranato(diisopropyl)phosphino]phenylphosphonate

Base Information

• Chemical Name: diethyl 2-[boranato(diisopropyl)phosphino]phenylphosphonate
• CAS No.: 549494-61-3
• Molecular Formula: C₁₆H₃₁BO₃P₂
• Molecular Weight: 344.179
• Mol file: 549494-61-3.mol

Synonyms:diethyl 2-[boranato(diisopropyl)phosphino]phenylphosphonate

Chemical Property of diethyl 2-[boranato(diisopropyl)phosphino]phenylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of diethyl 2-[boranato(diisopropyl)phosphino]phenylphosphonate

There total 1 articles about diethyl 2-[boranato(diisopropyl)phosphino]phenylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

Chlorodiisopropylphosphane (40244-90-4) + diethyl phenylphosphonate (1754-49-0) → diethyl 2-[boranato(diisopropyl)phosphino]phenylphosphonate (549494-61-3)

Guidance literature:

diethyl phenylphosphonate; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -78 ℃; for 2h;

Chlorodiisopropylphosphane; In tetrahydrofuran; hexane; at 20 ℃; for 16h;

With dimethylsulfide borane complex; In tetrahydrofuran; hexane; at 20 ℃; for 1h; Further stages.;

DOI:10.1002/adsc.200390008

Reference yield: 96.0%

diethyl 2-[boranato(diisopropyl)phosphino]phenylphosphonate (549494-61-3) → 2-[boranato(diisopropyl)phosphino]phenylphosphine (549494-62-4)

Guidance literature:

With lithium aluminium tetrahydride; chloro-trimethyl-silane; In tetrahydrofuran; at 20 ℃; for 16h;

DOI:10.1002/adsc.200390008

Reference yield:

diethyl 2-[boranato(diisopropyl)phosphino]phenylphosphonate (549494-61-3) → 1-diisopropylphosphino-2-((2S,5S)-2,5-dimethylphospholano)benzene

Guidance literature:

Multi-step reaction with 3 steps

1.1: 96 percent / trimethylsilyl chloride; lithium aluminium hydride / tetrahydrofuran / 16 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / 0 °C

2.2: tetrahydrofuran; hexane / 0 - 20 °C

2.3: 91 percent / n-butyllithium / tetrahydrofuran; hexane / 15 h / 20 °C

3.1: 100 percent / DABCO / toluene / 16 h / 75 °C

With 1,4-diaza-bicyclo[2.2.2]octane; lithium aluminium tetrahydride; n-butyllithium; chloro-trimethyl-silane; In tetrahydrofuran; hexane; toluene;

DOI:10.1002/adsc.200390008

upstream raw materials:

Chlorodiisopropylphosphane

diethyl phenylphosphonate

Downstream raw materials:

2-[boranato(diisopropyl)phosphino]phenylphosphine

Refernces