3-[4-(2,5-dichlorophenoxy)phenyl]-3-ethoxypropionic acid

Base Information

• Chemical Name: 3-[4-(2,5-dichlorophenoxy)phenyl]-3-ethoxypropionic acid
• CAS No.: 1202575-41-4
• Molecular Formula: C₁₇H₁₆Cl₂O₄
• Molecular Weight: 355.218
• Mol file: 1202575-41-4.mol

Synonyms:3-[4-(2,5-dichlorophenoxy)phenyl]-3-ethoxypropionic acid

Chemical Property of 3-[4-(2,5-dichlorophenoxy)phenyl]-3-ethoxypropionic acid

Chemical Property:

Purity/Quality:

95+% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[4-(2,5-dichlorophenoxy)phenyl]-3-ethoxypropionic acid

There total 5 articles about 3-[4-(2,5-dichlorophenoxy)phenyl]-3-ethoxypropionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

ethyl 3-[4-(2,5-dichlorophenoxy)phenyl]-3-ethoxy propionate (1202577-08-9) → 3-[4-(2,5-dichlorophenoxy)phenyl]-3-ethoxypropionic acid (1202575-41-4)

Guidance literature:

ethyl 3-[4-(2,5-dichlorophenoxy)phenyl]-3-ethoxy propionate; With water; sodium hydroxide; In tetrahydrofuran; ethanol; at 20 ℃; for 18h;

With hydrogenchloride; In tetrahydrofuran; ethanol; water;

Reference yield:

2,5-dichlorophenol (583-78-8) → 3-[4-(2,5-dichlorophenoxy)phenyl]-3-ethoxypropionic acid (1202575-41-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: caesium carbonate / ISOPROPYLAMIDE / 20 - 150 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C / Inert atmosphere

3.1: silver(l) oxide / toluene / 20 - 100 °C / Inert atmosphere

4.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 18 h / 20 °C

With water; caesium carbonate; sodium hydroxide; silver(l) oxide; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; ISOPROPYLAMIDE; toluene;

Reference yield:

4-fluorobenzaldehyde (459-57-4) → 3-[4-(2,5-dichlorophenoxy)phenyl]-3-ethoxypropionic acid (1202575-41-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: caesium carbonate / ISOPROPYLAMIDE / 20 - 150 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C / Inert atmosphere

3.1: silver(l) oxide / toluene / 20 - 100 °C / Inert atmosphere

4.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 18 h / 20 °C

With water; caesium carbonate; sodium hydroxide; silver(l) oxide; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; ISOPROPYLAMIDE; toluene;

upstream raw materials:

2,5-dichlorophenol

4-fluorobenzaldehyde

(25A) 4-(2,5-Dichlorophenoxy)benzaldehyde

ethyl 3-[4-(2,5-dichlorophenoxy)phenyl]-3-hydroxy propionate

Refernces