ethyl 3-[4-(2,5-dichlorophenoxy)phenyl]-3-ethoxy propionate

Base Information

• Chemical Name: ethyl 3-[4-(2,5-dichlorophenoxy)phenyl]-3-ethoxy propionate
• CAS No.: 1202577-08-9
• Molecular Formula: C₁₉H₂₀Cl₂O₄
• Molecular Weight: 383.271
• Mol file: 1202577-08-9.mol

Synonyms:ethyl 3-[4-(2,5-dichlorophenoxy)phenyl]-3-ethoxy propionate

Chemical Property of ethyl 3-[4-(2,5-dichlorophenoxy)phenyl]-3-ethoxy propionate

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-[4-(2,5-dichlorophenoxy)phenyl]-3-ethoxy propionate

There total 4 articles about ethyl 3-[4-(2,5-dichlorophenoxy)phenyl]-3-ethoxy propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

ethyl 3-[4-(2,5-dichlorophenoxy)phenyl]-3-hydroxy propionate (1202577-07-8) + ethyl iodide (75-03-6) → ethyl 3-[4-(2,5-dichlorophenoxy)phenyl]-3-ethoxy propionate (1202577-08-9)

Guidance literature:

With silver(l) oxide; In toluene; at 20 - 100 ℃; Inert atmosphere;

Reference yield:

2,5-dichlorophenol (583-78-8) → ethyl 3-[4-(2,5-dichlorophenoxy)phenyl]-3-ethoxy propionate (1202577-08-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: caesium carbonate / ISOPROPYLAMIDE / 20 - 150 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C / Inert atmosphere

3.1: silver(l) oxide / toluene / 20 - 100 °C / Inert atmosphere

With caesium carbonate; silver(l) oxide; lithium hexamethyldisilazane; In tetrahydrofuran; ISOPROPYLAMIDE; toluene;

Reference yield:

4-fluorobenzaldehyde (459-57-4) → ethyl 3-[4-(2,5-dichlorophenoxy)phenyl]-3-ethoxy propionate (1202577-08-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: caesium carbonate / ISOPROPYLAMIDE / 20 - 150 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: 1 h / -78 °C / Inert atmosphere

3.1: silver(l) oxide / toluene / 20 - 100 °C / Inert atmosphere

With caesium carbonate; silver(l) oxide; lithium hexamethyldisilazane; In tetrahydrofuran; ISOPROPYLAMIDE; toluene;

upstream raw materials:

ethyl 3-[4-(2,5-dichlorophenoxy)phenyl]-3-hydroxy propionate

ethyl iodide

2,5-dichlorophenol

4-fluorobenzaldehyde

Downstream raw materials:

3-[4-(2,5-dichlorophenoxy)phenyl]-3-ethoxypropionic acid

Refernces