nooglutil

Base Information

• Chemical Name: nooglutil
• CAS No.: 112193-35-8
• Molecular Formula: C₁₁H₁₂N₂O₆
• Molecular Weight: 268.226
• UNII: 09UM5JOS3W
• DSSTox Substance ID: DTXSID90920687
• Nikkaji Number: J440.159J
• Wikipedia: Nooglutyl
• Wikidata: Q15425767
• Mol file: 112193-35-8.mol

Synonyms:Nooglutil;Nooglutyl; ONK 10

Chemical Property of nooglutil

Chemical Property:

• Vapor Pressure: 7.59E-21mmHg at 25°C
• Boiling Point: 704.7°Cat760mmHg
• PKA: 3.15±0.10(Predicted)
• Flash Point: 380°C
• PSA: 140.31000
• Density: 1.514g/cm³
• LogP: 0.40980
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 6
• Exact Mass: 268.06953611
• Heavy Atom Count: 19
• Complexity: 359

Purity/Quality:

98% ^*data from raw suppliers

NOOGLUTIL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C=NC=C1O)C(=O)NC(CCC(=O)O)C(=O)O
• Isomeric SMILES: C1=C(C=NC=C1O)C(=O)N[C@@H](CCC(=O)O)C(=O)O
• Uses: N-(5-hydroxynicotinoyl)-L-glutamic acid can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Technology Process of nooglutil

There total 9 articles about nooglutil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) + 5-hydroxynicotinic acid azide (112193-40-5) → nooglutil (112193-35-8)

Guidance literature:

With sodium hydroxide; at 20 ℃; for 0.5h; pH 9-9.5;

DOI:10.1007/BF00764700

Reference yield:

diethyl N-(5-hydroxynicotinoyl)-L-glutamate → nooglutil (112193-35-8)

Guidance literature:

diethyl N-(5-hydroxynicotinoyl)-L-glutamate; With water; sodium hydroxide; at 20 ℃; for 2h;

With hydrogenchloride; In water; pH=4;

DOI:10.1134/S1070428019050063

Reference yield:

5-hydroxynicotinic acid hydrazide (112193-39-2) → nooglutil (112193-35-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / conc. HCl, NaNO₂ / H₂O / 0.5 h / 0 °C

2: 68 percent / 1 N NaOH / 0.5 h / 20 °C / pH 9-9.5

With hydrogenchloride; sodium hydroxide; sodium nitrite; In water;

DOI:10.1007/BF00764700

upstream raw materials:

L-glutamic acid

5-hydroxynicotinic acid azide

5-hydroxynicotinic acid hydrazide

ethyl 5-hydroxy-3-pyridinecarboxylate

Refernces

• 1、 Kuznetsova,Voronina,Khromova,Garibova,Tosina,Stolyarova,Troitskaya,Smirnov. "Synthesis and pharmacological activity of amino acid derivatives of nicotinic acid". . p. 943 - 949. Retrieved 2007/10/02.