2-(N-Methylanilino)ethanol

Base Information

• Chemical Name: 2-(N-Methylanilino)ethanol
• CAS No.: 93-90-3
• Molecular Formula: C9H13NO
• Molecular Weight: 151.208
• Hs Code.: 29221990
• European Community (EC) Number: 202-285-9
• NSC Number: 9274
• UNII: 48PV5540EO
• DSSTox Substance ID: DTXSID9059094
• Nikkaji Number: J53.965A
• Wikidata: Q27259164
• Mol file: 93-90-3.mol

Synonyms:93-90-3;2-(N-Methylanilino)ethanol;2-(Methyl(phenyl)amino)ethanol;N-(2-Hydroxyethyl)-N-methylaniline;2-(Methylphenylamino)ethanol;ETHANOL, 2-(METHYLPHENYLAMINO)-;Phenylmethylethanolamine;N-Methyl-N-hydroxyethylaniline;2-(N-Methylaniline)ethanol;2-(N-Methyl-N-phenylamino)ethanol;Phenylmethyl ethanol amine;Ethanol, 2-(N-methylanilino)-;N-Methyl-N-(2-hydroxyethyl)aniline;NSC 9274;N-Methyl-N-phenylethanolamine;N-Hydroxyethyl-N-methylaniline;2-(N-Fenyl-N-methylamino)ethanol;EINECS 202-285-9;BRN 2803140;UNII-48PV5540EO;2-(N-Fenyl-N-methylamino)ethanol [Czech];AI3-23878;2-[methyl(phenyl)amino]ethanol;N-Methyl-N-(hydroxyethyl)aniline;48PV5540EO;NSC-9274;N-Methyl-N-.beta.-hydroxyethylaniline;4-12-00-00280 (Beilstein Handbook Reference);n-Methyl-n-hydroxyethyl aniline;NSC9274;2-[methyl(phenyl)amino]ethan-1-ol;hydroxyethylmethylaniline;2-N-Methylanilinoethanol;2.N-Methylanilinoethanol;2-(Methylanilino)ethanol #;SCHEMBL56003;N-Methyl-N-2-ethanolaniline;WLN: Q2N1&R;n-phenyl-n-methyl-ethanolamine;DTXSID9059094;N-Hydroxyethyl-N-Methyl Aniline;N-(hydroxyethyl)-N-methylaniline;2(N-Methyl-N-phenyl amino)ethanol;2-(Methylphenylamino)ethanol, 98%;MFCD00020572;AKOS009067250;CS-W017743;AS-14307;LS-66873;FT-0629144;H0359;N-METHYL-N-PHENYL-2-HYDROXYETHYLAMINE;EN300-97784;F87320;A844732;Q27259164;Z138702688

Chemical Property of 2-(N-Methylanilino)ethanol

Chemical Property:

• Vapor Pressure: 0.00559mmHg at 25°C
• Melting Point: 77 °C
• Refractive Index: n20/D 1.573(lit.)
• Boiling Point: 262.2 °C at 760 mmHg
• PKA: 14.79±0.10(Predicted)
• Flash Point: 126.7 °C
• PSA: 23.47000
• Density: 1.06 g/cm³
• LogP: 1.11510
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 151.099714038
• Heavy Atom Count: 11
• Complexity: 99.7

Purity/Quality:

99% ^*data from raw suppliers

2-(N-Methylanilino)ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(CCO)C1=CC=CC=C1

Technology Process of 2-(N-Methylanilino)ethanol

There total 51 articles about 2-(N-Methylanilino)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

formic acid (64-18-6) + 2-Anilinoethanol (122-98-5) → N-(2-hydroxyethyl)-N-methylaminobenzene (93-90-3)

Guidance literature:

With cobalt(II) tetrafluoroborate hexahydrate; (p-anisyl)triphos; hydrogen; In 1,4-dioxane; at 100 ℃; for 24h; under 30003 Torr; Autoclave; Green chemistry;

DOI:10.1002/anie.201806132

Reference yield: 96.0%

(methyl-phenyl-amino)-acetic acid ethyl ester (21911-74-0) → N-(2-hydroxyethyl)-N-methylaminobenzene (93-90-3)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 ℃;

DOI:10.1002/anie.201709285

Reference yield: 93.0%

[1,3]-dioxolan-2-one (96-49-1) + N-methylaniline (100-61-8) → N-(2-hydroxyethyl)-N-methylaminobenzene (93-90-3)

Guidance literature:

With Na-Y zeolite; In Triethylene glycol dimethyl ether; for 6h; Heating;

DOI:10.1055/s-2006-939697

upstream raw materials:

oxirane

N-methylaniline

N-(2-methylphenyl)glycine ethyl ester

N,N-dimethyl-aniline

Downstream raw materials:

2-(N-methyl-4-phenylazo-anilino)-ethanol

N-Methyl,N-{(2-bromo)-1-ethyl}aniline

N-(2-chloroethyl)-N-methylaniline

succinic acid bis-[2-(N,N-dimethyl-anilinio)-ethyl ester]; diiodide

Refernces

• 1、 Zhang, Yanmeng,Zhang, He,Gao, Ke. "Borane-Trimethylamine Complex as a Reducing Agent for Selective Methylation and Formylation of Amines with CO2". supporting information. p. 8282 - 8286. Retrieved 2021/10/25.
• 2、 Xin, Zhuo,Jia, Le,Huang, Yuxing,Du, Chen-Xia,Li, Yuehui. "Ru-Catalyzed Switchable N-Hydroxyethylation and N-Acetonylation with Crude Glycerol". . p. 2007 - 2011. Retrieved 2020/03/19.