1-Benzyl-4-phenyl-4-piperidinecarboxylic Acid Hydrochloride

Base Information

• Chemical Name: 1-Benzyl-4-phenyl-4-piperidinecarboxylic Acid Hydrochloride
• CAS No.: 1013330-27-2
• Molecular Formula: C₁₉H₂₁NO₂*ClH
• Molecular Weight: 331.842
• Mol file: 1013330-27-2.mol

Synonyms:1-benzyl-4-phenylpiperidine-4-carboxylic acid hydrochloride

Chemical Property of 1-Benzyl-4-phenyl-4-piperidinecarboxylic Acid Hydrochloride

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

1-Benzyl-4-phenyl-4-piperidinecarboxylicAcidHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 1-Benzyl-4-phenyl-4-piperidinecarboxylic Acid Hydrochloride is a disubstituted piperidinecarboxylic acid used in the preparation of calcium channel blockers.

Technology Process of 1-Benzyl-4-phenyl-4-piperidinecarboxylic Acid Hydrochloride

There total 1 articles about 1-Benzyl-4-phenyl-4-piperidinecarboxylic Acid Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-benzyl-4-cyano-4-phenylpiperidine (56243-25-5) → 1-benzyl-4-phenylpiperidine-4-carboxylic acid hydrochloride (1013330-27-2)

Guidance literature:

With hydrogenchloride; water; Heating / reflux;

Reference yield: 66.0%

piperidine (110-89-4) + 1-benzyl-4-phenylpiperidine-4-carboxylic acid hydrochloride (1013330-27-2) → 1-(1-benzyl-4-phenyl-piperidine-4-carbonyl)-piperidine (95703-61-0)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dmap; In dichloromethane; at 20 ℃; for 48h;

Reference yield:

1-benzyl-4-phenylpiperidine-4-carboxylic acid hydrochloride (1013330-27-2) + 3,5-dimethylpiperazine (108-49-6) → (1-benzyl-4-phenylpiperidin-4-yl)(3,5-dimethylpiperazin-1-yl)methanone (1013330-13-6)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; dmap; In dichloromethane; at 20 ℃;

upstream raw materials:

1-benzyl-4-cyano-4-phenylpiperidine

Downstream raw materials:

1-(1-benzyl-4-phenyl-piperidine-4-carbonyl)-piperidine

(1-benzyl-4-phenylpiperidin-4-yl)(3,5-dimethylpiperazin-1-yl)methanone

Refernces