Pyrantel Pamoate

Base Information

• Chemical Name: Pyrantel Pamoate
• CAS No.: 22204-24-6
• Deprecated CAS: 122157-48-6
• Molecular Formula: C23H16O6^.C11H14N2S
• Molecular Weight: 594.68
• Hs Code.: 2934990002
• European Community (EC) Number: 244-837-1
• UNII: 81BK194Z5M
• ChEMBL ID: CHEMBL1599768
• DSSTox Substance ID: DTXSID40897057
• NCI Thesaurus Code: C75232
• NSC Number: 757303,355080
• RXCUI: 8985
• Wikidata: Q3489331
• Wikipedia: Pyrantel_pamoate
• Mol file: 22204-24-6.mol

Synonyms:Antiminth;Combantrin;Embonate, Pyrantel;Embovin;Pamoate, Pyrantel;Pyrantel Embonate;Pyrantel Pamoate

Chemical Property of Pyrantel Pamoate

Chemical Property:

• Appearance/Colour: Odorless light yellow to tan crystalline powder
• Vapor Pressure: 2.13E-17mmHg at 25°C
• Melting Point: 266-267 °C
• Boiling Point: 642.7 °C at 760 mmHg
• Flash Point: 356.5 °C
• PSA: 158.90000
• LogP: 6.26020
• Storage Temp.: 0-6°C
• Solubility.: Pratically insoluble in water, soluble in dimethyl sulfoxide, pratically insoluble in methanol.
• Water Solubility.: <0.1 g/100 mL at 19℃
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 6
• Exact Mass: 594.18245785
• Heavy Atom Count: 43
• Complexity: 816

Purity/Quality:

99% ^*data from raw suppliers

Pyrantel Pamoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CN1CCCN=C1C=CC2=CC=CS2.C1=CC=C2C(=C1)C=C(C(=C2CC3=C(C(=CC4=CC=CC=C43)C(=O)O)O)O)C(=O)O
• Isomeric SMILES: CN1CCCN=C1/C=C/C2=CC=CS2.C1=CC=C2C(=C1)C=C(C(=C2CC3=C(C(=CC4=CC=CC=C43)C(=O)O)O)O)C(=O)O
• Recent ClinicalTrials: Triple Combinations Against Hookworm Infections in Lao
• Uses: An antiparasitic agent used in the treatment of intestinal parasites such as hookworms and roundworms (Ascaris lumbricoides, aka ascarids in humans) in domesticated animals such as horses, cattle, sheep, pigs, cats, dogs, and many other species. anthelmintic
• Indications: Pyrantel pamoate (Antiminth) is a agonist at the nicotinic acetylcholine receptor, and its actions result in depolarization and spastic paralysis of the helminth muscle. Its selective toxicity occurs primarily because the neuromuscular junction of helminth muscle is more sensitive to the drug than is mammalian muscle. This drug is administered orally, and because very little is absorbed, high levels are achieved in the intestinal tract. Less than 15% of the drug and its metabolites are excreted in urine.
• Clinical Use: Trans-1,4,5,6,-Tetrahydro-1-methyl-2-[2-(2 -thienyl)ethenyl]pyrimidine pamoate (Antiminth) is a depolarizing neuromuscularblocking agent that causes spastic paralysis insusceptible helminths. It is used in the treatment of infestationscaused by pinworms and roundworms (ascariasis).Because its action opposes that of piperazine, the twoanthelmintics should not be used together. More than halfof the oral dose is excreted in the feces unchanged.Adverse effects associated with its use are primarilygastrointestinal.