Technology Process of (2R,3S,4R)-1-benzyl 2-methyl 4-hydroxy-3-methylpyrrolidine-1,2-dicarboxylate
There total 6 articles about (2R,3S,4R)-1-benzyl 2-methyl 4-hydroxy-3-methylpyrrolidine-1,2-dicarboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
at 20 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 1H-imidazole / dichloromethane / 20 °C
2.1: sode de l'acide trichloroisocyanurique / water; toluene / 0.5 h / 0 °C
2.2: 1 h / 0 °C
3.1: 2,6-dimethylpyridine / dichloromethane / -10 - 20 °C
4.1: copper(I) bromide dimethylsulfide complex / diethyl ether / 0.75 h / -45 °C
5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C
With
1H-imidazole; 2,6-dimethylpyridine; copper(I) bromide dimethylsulfide complex; tetrabutyl ammonium fluoride; sode de l'acide trichloroisocyanurique;
In
tetrahydrofuran; diethyl ether; dichloromethane; water; toluene;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: copper(I) bromide dimethylsulfide complex / diethyl ether / 1 h
1.2: 0.75 h / -45 °C
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 20 °C
With
copper(I) bromide dimethylsulfide complex; tetrabutyl ammonium fluoride;
In
tetrahydrofuran; diethyl ether;