1367552-62-2

Basic information

• Product Name: 1-benzyl 2-methyl (R)-4-((tert-butyldimethylsilyl)oxy)-4.5-dihydro-1H-pyrrole-1,2-dicarboxylate
• Synonyms: 1-benzyl 2-methyl (R)-4-((tert-butyldimethylsilyl)oxy)-4.5-dihydro-1H-pyrrole-1,2-dicarboxylate
• CAS NO: 1367552-62-2
• Molecular Weight: 391.539
• Mol File: 1367552-62-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-benzyl 2-methyl (R)-4-((tert-butyldimethylsilyl)oxy)-4.5-dihydro-1H-pyrrole-1,2-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl 2-methyl (R)-4-((tert-butyldimethylsilyl)oxy)-4.5-dihydro-1H-pyrrole-1,2-dicarboxylate(1367552-62-2)
• EPA Substance Registry System: 1-benzyl 2-methyl (R)-4-((tert-butyldimethylsilyl)oxy)-4.5-dihydro-1H-pyrrole-1,2-dicarboxylate(1367552-62-2)

Safety Data

• Hazardous Substances Data: 1367552-62-2(Hazardous Substances Data)

Upstream product

• 501-53-1 benzyl chloroformate 
• 1392481-48-9 C₁₂H₂₄ClNO₃Si 
• 117460-96-5 methyl (2S,4R)-4-((tert-butyldimethylsilyl)oxy)pyrrolidine-2-carboxylate 
• 1367552-60-0 (R)-methyl 3-((tert-butyldimethylsilyl)oxy)-3,4-dihydro-2H-pyrrole-5-carboxylate 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 

Downstream Products

• 1279701-25-5 C₂₁H₃₃NO₅Si 
• 1367552-64-4 (2R,3S,4R)-1-benzyl 2-methyl 4-((tert-butyldimethylsilyl)oxy)-3-methylpyrrolidine-1,2-dicarboxylate 
• 1367553-87-4 C₃₀H₄₀N₄O₅S 
• 1610035-72-7 2-((2S,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin4-yl)oxy)-3-fluorophenyl)-4-methoxy-3-methylpyrrolidin-2-yl)acetic acid 
• 1610035-74-9 ((2R,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-3-fluorophenyl)-4-methoxy-3-methylpyrrolidin-2-yl)methanol 
• 1610035-75-0 ((2R,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-3-fluorophenyl)-4-methoxy-3-methylpyrrolidin-2-yl)methyl methanesulfonate 
• 1610035-76-1 2-((2S,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-3-fluorophenyl)-4-methoxy-3-methylpyrrolidin-2-yl)acetonitrile 
• 1610036-01-5 2-((2S,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-2-fluorophenyl)-4-methoxy-3-methylpyrrolidin-2-yl)acetic acid 
• 1610036-03-7 ((2R,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-2-fluorophenyl)-4-methoxy-3-methylpyrrolidin-2-yl)methanol 
• 1610036-04-8 2-((2S,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-2-fluorophenyl)-4-methoxy-3-methylpyrrolidin-2-yl)acetonitrile 
• 1610036-05-9 methyl 2-((2S,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-2-fluorophenyl)-4-methoxy-3-methylpyrrolidin-2-yl)acetate 
• 1610036-10-6 2-((2S,3S,4R)-1-(4-(((3,4-trans)-1-(5-chloro-2-methoxypyridin-4-yl)-3-methylpiperidin-4-yl)oxy)-2-fluorophenyl)-4-hydroxy-3-methylpyrrolidin-2-yl)acetic acid 
• 1610039-11-6 ((2R,3S,4R)-1-(2-fluoro-4-methoxyphenyl)-4-methoxy-3-methylpyrrolidin-2-yl)methanol 
• 1610036-11-7 2-((2S,3S,4R)-1-(2-fluoro-4-methoxyphenyl)-4-methoxy-3methylpyrrolidin-2-yl)acetonitrile 

Relevant articles and documents

PYRROLIDINE GPR40 MODULATORS

The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph, or a solvate thereof, wherein all of the variables are as defined herein. These compounds are GPR40 G protein-coupled receptor modulators which may be used as medicaments.

SUBSTITUTED PROLINE INHIBITORS OF HEPATITIS C VIRUS REPLICATION

The embodiments provide compounds of the general Formulae I, la, II,IIa,III, IIIa, Illb, IV, IVa, IVb, V, Va, Vb, VI, VIa, VIb, and VIc, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition. The embodiments also provide methods for the synthesis of subject compounds and intermediates in the synthetic methods.