APOATROPINE

Base Information

• Chemical Name: APOATROPINE
• CAS No.: 500-55-0
• Molecular Formula: C17H21 N O2
• Molecular Weight: 271.359
• Hs Code.: 2933990090
• Mol file: 500-55-0.mol

Synonyms:1aH,5aH-Tropan-3a-ol, atropate (ester) (8CI); Apoatropine (6CI,7CI); Benzeneacetic acid, a-methylene-,8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester, endo-; Apoatropin; Apohyoscyamin;Apohyoscyamine; Atropamin; Atropamine; Atropyltropeine

Chemical Property of APOATROPINE

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 62°
• Refractive Index: 1.5675 (estimate)
• Boiling Point: 389.1°Cat760mmHg
• PKA: 10.01±0.40(Predicted)
• Flash Point: 136.5°C
• PSA: 29.54000
• Density: 1.13g/cm³
• LogP: 2.80610

Purity/Quality:

98%min ^*data from raw suppliers

Apoatropine ^*data from reagent suppliers

Safty Information:

• Statements: 26/28
• Safety Statements: 25-45

MSDS Files:

Useful:

• Uses: Apoatropine is an alkaloid derivative with the potential to be an antibacterial.

Technology Process of APOATROPINE

There total 18 articles about APOATROPINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

Atropine (51-55-8) → apoatropine (500-55-0)

Guidance literature:

Atropine; With copper(l) chloride; diisopropyl-carbodiimide; at 60 ℃; for 1h; Sealed tube; Microwave irradiation;

With copper (II)-fluoride; In water; at 100 ℃; for 24h; Microwave irradiation;

DOI:10.1002/anie.202001015

Reference yield:

→ apoatropine (500-55-0)

Guidance literature:

With potassium hydroxide;

Reference yield:

→ apoatropine (500-55-0)

Guidance literature:

With potassium hydroxide; diethyl ether; water;

upstream raw materials:

acetic anhydride

Hyoscyamine

benzoic acid anhydride

(1R,3r,5S)-3-tropoyloxytropanium sulfate

Downstream raw materials:

(1R,3r,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl 2,3-dihydroxy-2-phenylpropanoate

2-phenylacrylic acid

Tropanol

atropic acid tropane-3endo-yl ester; hydrochloride

Refernces

• 1、 Wleklinski, Michael,Falcone, Caitlin E.,Loren, Bradley P.,Jaman, Zinia,Iyer, Kiran,Ewan, H. Samuel,Hyun, Seok-Hee,Thompson, David H.,Cooks, R. Graham. "Can Accelerated Reactions in Droplets Guide Chemistry at Scale?". . p. 5480 - 5484. Retrieved 2016/11/26.
• 2、 Jira,Pohloudek-Fabini. "Analysis and stability of atropine sulfate and scopolamine hydrobromide. 1. Qualitative detection of alkaloids in the presence of their decomposition products. 73. Contribution to the problem of the use of plastic receptacles for liquid pharmaceuticals". . p. 645 - 649. Retrieved 2007/10/02.