2-Hydroxyethyl oleate

Base Information

• Chemical Name: 2-Hydroxyethyl oleate
• CAS No.: 4500-01-0
• Deprecated CAS: 8034-24-0
• Molecular Formula: C20H38 O3
• Molecular Weight: 326.52
• Hs Code.: 2916150000
• European Community (EC) Number: 224-806-9,500-015-7
• UNII: 9Z5UXZ64XA
• DSSTox Substance ID: DTXSID0063498
• Nikkaji Number: J46.859B
• Wikidata: Q27273405
• RXCUI: 1363616,2534443
• ChEMBL ID: CHEMBL3182752
• Mol file: 4500-01-0.mol

Synonyms:2-Hydroxyethyl oleate;Glycol oleate;4500-01-0;Ethylene glycol monooleate;2-hydroxyethyl (Z)-octadec-9-enoate;9-Octadecenoic acid (Z)-, 2-hydroxyethyl ester;Cithrol A;Glycol monooleate;Oleic acid, 2-hydroxyethyl ester;9-Octadecenoic acid (9Z)-, 2-hydroxyethyl ester;UNII-9Z5UXZ64XA;9Z5UXZ64XA;9004-96-0;EINECS 224-806-9;Rokacet;Prodhyphore B;Cemulsol A;Emulphor A;Slovasol A;Ethofat O;Lannagol LF;Cithrol PO;Olepal I;Trydet OS series;Olepal III;Ethylan A3;Ethylan A6;Cemulsol D-8;Nonion O2;Nonion O4;Nopalcol 4-O;Oleox 5;Rokacet O 7;PEG-6 oleate;Akyporox O 50;Nopalcol 1-0;Nopalcol 6-0;Pegosperse 400MO;Crodet O 6;Nikkol MYO 2;Nonion 06;PEG-5 Oleate;PEG-7 Oleate;PEG-8 Oleate;PEG-9 Oleate;Unisol 4-O;Ethofat O 15;Nonisol 200;POOA;Cemulsol 1050;Cemulsol C 105;Emcol H-2A;Emulphor UN-430;Emulphor VN 430;Chemester 300-OC;Lipal 30W;Nonex 25;Nonex 30;Nonex 52;Nonex 64;Witco 31;Empilan BP 100;Empilan BQ 100;Extrex P 60;Nikkol MYO 10;PEG-10 Oleate;PEG-11 Oleate;PEG-12 Oleate;PEG-14 Oleate;PEG-15 Oleate;PEG-20 Oleate;PEG-32 Oleate;PEG-36 Oleate;PEG-75 Oleate;Emerest 2646;Emerest 2660;Lipal 400-ol;Macrogol oleate 600;Emcol H 31A;PEG-150 Oleate;Noigen ES 160;Emanon 4115;Ionet MO-400;Atlas G-2142;Atlas G-2144;PEG 200MO;PEG 600MO;OK 7;PEG 1000MO;X-539-R;Unisol 4;PEG OLEATE;S 1006;S 1132;2- hydroxyethyl oleate;PEG-150 Monooleate;PEG-200 Monooleate;PEG-300 Monooleate;PEG-400 Monooleate;PEG-600 Monooleate;ethyleneglycol monooleate;9-Octadecenoic acid, 2-hydroxyethyl ester;AEC GLYCOL OLEATE;PEG-1000 Monooleate;UNII-7W4ZYQ7UVQ;UNII-MNB8P1NH2O;DSSTox_CID_7713;PEG-23 OLEATE;UNII-403GW4INKC;UNII-9LAA30N8CO;UNII-BQQ46WC93L;UNII-Y9BH8M3UA0;DSSTox_RID_78546;UNII-1QP5V188NK;UNII-3IK2M53J2M;UNII-83DYX54F3A;UNII-9QL37EC4J7;UNII-P96Z85D7UU;UNII-X9940LGO8G;DSSTox_GSID_27713;SCHEMBL93861;GLYCOL OLEATE [INCI];UNII-2FD90866XK;UNII-4AG5694AB3;UNII-5B116SR6U7;14-Hydroxy-3,6,9,12-tetraoxatetradec-1-yl-9-octadecenoic acid;2-Hydroxyethyl 9-octadecenoate;CHEMBL3182752;DTXSID0063498;Poly(ethylene glycol) monooleate;UNII-389T9L615J;MUHFRORXWCGZGE-KTKRTIGZSA-N;UNII-0240V77G50;UNII-668U70616Y;Tox21_303475;ethylene glycol monooleate, AldrichCPR;(C2-H4-O)mult-C18-H34-O2;2-hydroxyethyl (9Z)-octadec-9-enoate;2-Hydroxyethyl (9Z)-9-octadecenoate #;NCGC00257333-01;CAS-9004-96-0;D08973;F71263;500-015-7 (NLP #);9-Octadecenoic acid, 2-hydroxyethyl ester, (Z)-;(Z)-9-OCTADECENOIC ACID-2-HYDROXYETHYL ESTER;Q27273405;Poli (oxi-1,2-etanodiil), alfa-[(9z)-1-oxo-9-octadecen-1-il]-w-hidroxi-

Chemical Property of 2-Hydroxyethyl oleate

Chemical Property:

• PSA: 46.53000
• LogP: 5.55940
• XLogP3: 6.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 18
• Exact Mass: 326.28209507
• Heavy Atom Count: 23
• Complexity: 274

Purity/Quality:

99.9% ^*data from raw suppliers

2-HydroxyethylOleate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Other Classes -> Polyoxyethylenes
• Canonical SMILES: CCCCCCCCC=CCCCCCCCC(=O)OCCO
• Isomeric SMILES: CCCCCCCC/C=C\CCCCCCCC(=O)OCCO
• Uses: Potential organic pollutant.

Technology Process of 2-Hydroxyethyl oleate

There total 4 articles about 2-Hydroxyethyl oleate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

cis-Octadecenoic acid (112-80-1,2027-47-6) + ethylene glycol (107-21-1) → glycol oleate (4500-01-0,25905-73-1,9004-96-0)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; at 110 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.bmcl.2017.07.041

Reference yield:

(Z)-9-octadecenoyl chloride (112-77-6) + ethylene glycol (107-21-1) → glycol oleate (4500-01-0,25905-73-1,9004-96-0)

Guidance literature:

With pyridine; Yield given;

DOI:10.1016/0040-4039(96)01802-3

Reference yield:

sodium Oleate (143-19-1) + 2-bromoethanol (540-51-2) → glycol oleate (4500-01-0,25905-73-1,9004-96-0)

Guidance literature:

With xylene; at 140 ℃;

upstream raw materials:

cis-Octadecenoic acid

ethylene glycol

sodium Oleate

2-bromoethanol

Downstream raw materials:

(Z)-Octadec-9-enoic acid 2-(bis-benzyloxy-phosphoryloxy)-ethyl ester

Refernces

• 1、 -. "Disulfide bond bridged docetaxel-fatty acid prodrugs and self-assembled nanoparticles thereof". Paragraph 0034-0035. . Retrieved 2021/04/07.
• 2、 Lynch, Kevin R.,Hopper, Darrin W.,Carlisle, Steven J.,Catalano, John G.,Zhang, Ming,Macdonald, Timothy L.. "Structure/activity relationships in lysophosphatidic acid: The 2- hydroxyl moiety". . p. 75 - 81. Retrieved 2007/10/03.