(+/-)-3-(4-isopropyl-2-methylphenyl)-2-methylpropanal

Base Information

• Chemical Name: (+/-)-3-(4-isopropyl-2-methylphenyl)-2-methylpropanal
• CAS No.: 180274-31-1
• Molecular Formula: C₁₄H₂₀O
• Molecular Weight: 204.312
• Mol file: 180274-31-1.mol

Synonyms:(+/-)-3-(4-isopropyl-2-methylphenyl)-2-methylpropanal

Chemical Property of (+/-)-3-(4-isopropyl-2-methylphenyl)-2-methylpropanal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-3-(4-isopropyl-2-methylphenyl)-2-methylpropanal

There total 4 articles about (+/-)-3-(4-isopropyl-2-methylphenyl)-2-methylpropanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(+/-)-3-(4-isopropyl-2-methylphenyl)-2-methylpropan-1-ol (180274-26-4) → (+/-)-3-(4-isopropyl-2-methylphenyl)-2-methylpropanal (180274-31-1)

Guidance literature:

With pyridinium chlorochromate; In dichloromethane; for 15h; Ambient temperature;

DOI:10.1002/hlca.19960790418

Reference yield:

2-methyl-3-[4-(methylethyl)phenyl]propanol (4756-19-8,77897-28-0) → (+/-)-3-(4-isopropyl-2-methylphenyl)-2-methylpropanal (180274-31-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 74 percent / LiBr, toluene-4-sulfonic acid hydrate / 15 h / Ambient temperature

2: 79 percent / AlCl₃ / CH₂Cl₂ / 1 h / 3 - 4 °C

3: 98 percent / hydrogen / 5percent Pd/C / ethyl acetate; ethanol / 15 h / 760 Torr / Ambient temperature

4: 72 percent / pyridinium chlorochromate / CH₂Cl₂ / 15 h / Ambient temperature

With aluminium trichloride; hydrogen; toluene-4-sulfonic acid; pyridinium chlorochromate; lithium bromide; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate;

DOI:10.1002/hlca.19960790418

Reference yield:

(+/-)-1,3,4,5-tetrahydro-8-isopropyl-4-methyl-2-benzoxepin (180274-21-9) → (+/-)-3-(4-isopropyl-2-methylphenyl)-2-methylpropanal (180274-31-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / hydrogen / 5percent Pd/C / ethyl acetate; ethanol / 15 h / 760 Torr / Ambient temperature

2: 72 percent / pyridinium chlorochromate / CH₂Cl₂ / 15 h / Ambient temperature

With hydrogen; pyridinium chlorochromate; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate;

DOI:10.1002/hlca.19960790418

upstream raw materials:

(+/-)-3-(4-isopropyl-2-methylphenyl)-2-methylpropan-1-ol

2-methyl-3-[4-(methylethyl)phenyl]propanol

(+/-)-1,3,4,5-tetrahydro-8-isopropyl-4-methyl-2-benzoxepin

1-Isopropyl-4-(3-methoxymethoxy-2-methyl-propyl)-benzene

Refernces