Cyclamen alcohol

Base Information

• Chemical Name: Cyclamen alcohol
• CAS No.: 4756-19-8
• Molecular Formula: C₁₃H₂₀O
• Molecular Weight: 192.301
• European Community (EC) Number: 225-289-2
• UNII: 95F15D1R7B
• DSSTox Substance ID: DTXSID90863449
• Nikkaji Number: J5.171C
• Wikidata: Q27893768
• Mol file: 4756-19-8.mol

Synonyms:2-methyl-3-cumenylpropanol;alpha-methyl-p-isopropylhydrocinnamic alcohol;cyclamen alcohol

Chemical Property of Cyclamen alcohol

Chemical Property:

• Vapor Pressure: 0.00086mmHg at 25°C
• Boiling Point: 292°Cat760mmHg
• Flash Point: 115.1°C
• PSA: 20.23000
• Density: 0.946g/cm³
• LogP: 2.98090
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 192.151415257
• Heavy Atom Count: 14
• Complexity: 145

Purity/Quality:

99% ^*data from raw suppliers

CyclamenAlcohol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)C1=CC=C(C=C1)CC(C)CO
• Uses: 3-(p-cumenyl)-2-methylpropanol is a cyclamen alcohol, a fragrance raw material, and thus can be used in the perfume industry. Cyclamen Alcohol, is a fragrance raw material, and thus can be used in the perfume industry.

Technology Process of Cyclamen alcohol

There total 15 articles about Cyclamen alcohol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

cyclamenaldehyde (103-95-7,80949-77-5) → 2-methyl-3-[4-(methylethyl)phenyl]propanol (4756-19-8,77897-28-0)

Guidance literature:

With zirconium(IV) oxide; In isopropyl alcohol; for 5h; Heating;

DOI:10.1246/cl.1985.731

Reference yield: 71.0%

propan-1-ol (71-23-8) + cuminol (536-60-7) → 2-methyl-3-[4-(methylethyl)phenyl]propanol (4756-19-8,77897-28-0)

Guidance literature:

With tris(triphenylphosphine)ruthenium(II) chloride; potassium tert-butylate; In toluene; at 120 ℃; for 24h;

DOI:10.1021/acs.joc.8b01558

Reference yield: 71.0%

α-methyl-p-isopropylcinnamaldehyde (831-97-0) → 2-methyl-3-[4-(methylethyl)phenyl]propanol (4756-19-8,77897-28-0)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In methanol; for 24h;

DOI:10.1039/c3ra00114h

upstream raw materials:

4-(4-isopropyl-phenyl)-5-methyl-[1,3]dioxane

3t-(4-isopropyl-phenyl)-2-methyl-allyl alcohol

α-methyl-p-isopropylcinnamaldehyde

cyclamenaldehyde

Downstream raw materials:

3-(4-isopropylphenyl)-2-methylpropyl acetate

1-Isopropyl-4-(3-methoxymethoxy-2-methyl-propyl)-benzene

(+/-)-3-(4-isopropyl-2-methylphenyl)-2-methylpropan-1-ol

(+/-)-3-(4-isopropyl-2-methylphenyl)-2-methylpropanal

Refernces

• 1、 Vrbkov, Eva,Skpala, Tom,Vyskoilov, Elika,erven, Libor. "Cyclamen aldehyde synthesis: Aldol condensation followed by hydrogenation over ruthenium catalyst". . p. 9195 - 9205. Retrieved 2015/03/04.
• 2、 Limnios, Dimitris,Kokotos, Christoforos G.. "Microwave-assisted organocatalytic cross-aldol condensation of aldehydes". . p. 4496 - 4499. Retrieved 2013/05/09.