Triamcinolone hexacetonide

Base Information

• Chemical Name: Triamcinolone hexacetonide
• CAS No.: 5611-51-8
• Molecular Formula: C30H41 F O7
• Molecular Weight: 532.65
• Hs Code.: 2937220000
• European Community (EC) Number: 227-031-4
• UNII: I7GT1U99Y9
• DSSTox Substance ID: DTXSID0048634
• Nikkaji Number: J8.026H
• Wikipedia: Triamcinolone_hexacetonide
• Wikidata: Q1593246
• NCI Thesaurus Code: C48026
• RXCUI: 38546
• Pharos Ligand ID: 3UVHZF99D9YF
• Metabolomics Workbench ID: 67677
• ChEMBL ID: CHEMBL1200878
• Mol file: 5611-51-8.mol

Synonyms:9-fluoro-11 beta,16 alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone, 21-(3,3-dimethylbutyrate);Aristospan;triamcinolone hexacetonide

Chemical Property of Triamcinolone hexacetonide

Chemical Property:

• Vapor Pressure: 6.1E-18mmHg at 25°C
• Melting Point: 295-296° (dec); mp 271-272° (dec)
• Boiling Point: 619.5 ºC
• PKA: 13.09±0.70(Predicted)
• Flash Point: 328.5 ºC
• PSA: 99.13000
• Density: 1.24 g/cm³
• LogP: 4.40590
• Storage Temp.: 2-8°C
• Solubility.: Practically insoluble in water, sparingly soluble in anhydrous ethanol and in methanol.
• XLogP3: 4.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 6
• Exact Mass: 532.28363180
• Heavy Atom Count: 38
• Complexity: 1130

Purity/Quality:

98% ^*data from raw suppliers

Triamcinolone hexacetonide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(OC2CC3C4CCC5=CC(=O)C=CC5(C4(C(CC3(C2(O1)C(=O)COC(=O)CC(C)(C)C)C)O)F)C)C
• Isomeric SMILES: C[C@]12C[C@@H]([C@]3([C@H]([C@@H]1C[C@@H]4[C@]2(OC(O4)(C)C)C(=O)COC(=O)CC(C)(C)C)CCC5=CC(=O)C=C[C@@]53C)F)O
• Recent ClinicalTrials: Strategies Towards Personalised Treatment in Juvenile Idiopathic Arthritis (JIA).
• Recent EU Clinical Trials: A Randomized, Double-Blind, Active Comparator Controlled, Multi-Center Study of a Single Injection Cross-Linked Sodium Hyaluronate Combined with Triamcinolone Hexacetonide (Cingal?) to Provide Symptomatic Relief of Osteoarthritis of the Knee
• Uses: Triamcinolone Hexacetonide is the Intra-articular glucocorticoid treatment for rheumatoid arthritis.

Technology Process of Triamcinolone hexacetonide

There total 1 articles about Triamcinolone hexacetonide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ triamcinolone hexacetonide (5611-51-8)

Guidance literature:

9α-Fluor-11β,21-dihydroxy-16α,17α-isopropylidendihydroxy-1,4-pregnadien-3,20-dion, t-Butylacetanhydrid/Py.;