2-[(4-Methoxyphenoxy)methyl]oxirane

Base Information

• Chemical Name: 2-[(4-Methoxyphenoxy)methyl]oxirane
• CAS No.: 2211-94-1
• Molecular Formula: C10H12 O3
• Molecular Weight: 180.203
• Hs Code.: 29109000
• European Community (EC) Number: 218-653-7
• NSC Number: 126709,26796
• UNII: JY25P7XTV5
• DSSTox Substance ID: DTXSID201305536
• Nikkaji Number: J299.165I
• Wikidata: Q106902890
• Mol file: 2211-94-1.mol

Synonyms:2211-94-1;2-[(4-Methoxyphenoxy)methyl]oxirane;Glycidyl 4-methoxyphenyl ether;2,3-Epoxypropyl-4-methoxyphenyl ether;2-((4-Methoxyphenoxy)methyl)oxirane;p-Methoxyphenyl glycidyl ether;Methoxyphenyl glycidyl ether;Glycidyl p-methoxyphenyl ether;2-(p-Methoxyphenoxymethyl)oxirane;((4-Methoxyphenoxy)methyl)oxirane;Anisole, p-(2,3-epoxypropoxy)-;Benzene, 1-(2,3-epoxypropoxy)-4-methoxy-;NSC 26796;2,3-Epoxypropyl p-methoxyphenyl ether;NSC 126709;Oxirane, [(4-methoxyphenoxy)methyl]-;EINECS 218-653-7;NSC-26796;NSC-126709;Oxirane, ((4-methoxyphenoxy)methyl)-;BRN 0128888;2,3-Epoxypropyl 4'-methoxyphenyl ether;2,3-Epoxypropyl para-methoxyphenyl ether;[(4-methoxyphenoxy)methyl]oxirane;2,3-Epoxypropyl 4-methoxyphenyl ether;4-methoxyphenoxymethyloxirane;JY25P7XTV5;4-methoxyphenylglycidyl ether;SCHEMBL410250;4-methoxyphenyl glycidyl ether;DTXSID201305536;NSC26796;NSC126709;STK802523;(+/-)-O-(4-Methoxyphenyl)glycidol;Glycidyl 4-methoxyphenyl ether, 99%;AKOS000122886;AKOS016037122;1,2-epoxy-3-(4-methoxyphenoxy)propane;1-(p-Methoxyphenoxy)-2,3-epoxypropane;2-[(4-Methoxyphenoxy)methyl]oxirane #;1-(4-Methoxyphenoxy)-2,3-epoxypropane;3-(4-Methoxyphenoxy)-1,2-epoxypropane;LS-30070;Oxirane, 2-[(4-methoxyphenoxy)methyl]-;CS-0197032;FT-0634130;FT-0695382;EN300-22425;1,2-EPOXY-3-(P-METHOXYPHENOXY)PROPANE;6N-803;E78142;5-17-03-00025 (Beilstein Handbook Reference);A815941;Z147642770

Chemical Property of 2-[(4-Methoxyphenoxy)methyl]oxirane

Chemical Property:

• Melting Point: 45-48 °C(lit.)
• Refractive Index: 1.5430 (estimate)
• Boiling Point: 287.9°Cat760mmHg
• Flash Point: 95.5°C
• PSA: 30.99000
• Density: 1.142g/cm³
• LogP: 1.47280
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 180.078644241
• Heavy Atom Count: 13
• Complexity: 152

Purity/Quality:

98%,99%, ^*data from raw suppliers

Glycidyl 4-methoxyphenyl ether ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 7/9-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)OCC2CO2
• Uses: Glycidyl 4-Methoxyphenyl Ether is used as a catalyst in the radical polymerization of styrene.

Technology Process of 2-[(4-Methoxyphenoxy)methyl]oxirane

There total 55 articles about 2-[(4-Methoxyphenoxy)methyl]oxirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(2s)-(+)-glycidyl 3-nitrobenzenesulfonate (115314-14-2) + 4-methoxy-phenol (150-76-5) → (2S)-2-{[4-(methoxy)phenoxy]methyl}oxirane (2211-94-1,51469-79-5,71031-04-4,71048-65-2,26744-15-0)

Guidance literature:

With cesium fluoride; In N,N-dimethyl-formamide; at 25 ℃; for 16h;

DOI:10.1016/S0040-4020(99)00896-0

Reference yield: 91.0%

(R)-1-Chloro-3-(4-methoxy-phenoxy)-propan-2-ol (142037-06-7) → (2S)-2-{[4-(methoxy)phenoxy]methyl}oxirane (2211-94-1,51469-79-5,71031-04-4,71048-65-2,26744-15-0)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; for 22h; Ambient temperature;

DOI:10.3987/COM-91-5934

Reference yield: 89.0%

(R)-(-)-epichlorohydrin (51594-55-9,24969-06-0,13403-37-7) + 4-methoxy-phenol (150-76-5) → (2S)-2-{[4-(methoxy)phenoxy]methyl}oxirane (2211-94-1,51469-79-5,71031-04-4,71048-65-2,26744-15-0)

Guidance literature:

With sodium hydroxide; benzyltrimethylammonium chloride; In water; toluene; at 0 - 20 ℃; for 35.67h;

upstream raw materials:

4-methoxy-phenol

epichlorohydrin

allyl (4-methoxyphenyl) ether

1,2-Epoxy-3-bromopropane

Downstream raw materials:

1-(4-methoxy-phenoxy)-3-piperidin-1-yl-propan-2-ol

(2S)-2-{[4-(methoxy)phenoxy]methyl}oxirane

4-methoxybenzyloxy ester of (S)-glycidol

(R)-3-(p-methoxyphenoxy)-1,2-propanediol

Refernces

• 1、 -. "Substituted diaryl compound and preparation method and application thereof". Paragraph 0073-0075; 0076. . Retrieved 2021/09/15.
• 2、 -. "DIACYLGLYCEROL LACTONE COMPOUND, PREPARATION METHOD THEREFOR, AND IMMUNOSTIMULATOR CONTAINING SAME AS ACTIVE INGREDIENT". Paragraph 0034. . Retrieved 2021/01/26.