Technology Process of (S)-(4-fluorophenyl)(naphthalen-1-yl)methanol
There total 4 articles about (S)-(4-fluorophenyl)(naphthalen-1-yl)methanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-flourophenylmagnesium bromide;
With
aluminum (III) chloride;
In
tetrahydrofuran;
at 20 ℃;
Inert atmosphere;
With
Bis<2-(N,N-dimethylamino)aethyl>aether;
In
tetrahydrofuran;
at 20 ℃;
for 0.5h;
Inert atmosphere;
1-naphthaldehyde;
With
titanium(IV)isopropoxide; (S)-5,5',6,6',7,7',8,8'-octahydro-1,1'-bi-2-naphthol;
In
tetrahydrofuran;
at 20 ℃;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
DOI:10.1002/chem.201000974
- Guidance literature:
-
tris(4-fluorophenyl)aluminum;
With
4-methyl-morpholine;
In
tetrahydrofuran; hexane;
for 0.5h;
Inert atmosphere;
With
titanium(IV) isopropylate; (S)-[1,1']-binaphthalenyl-2,2'-diol;
In
tetrahydrofuran; hexane;
for 1h;
Inert atmosphere;
1-naphthaldehyde;
In
tetrahydrofuran; hexane;
at 40 ℃;
for 8h;
enantioselective reaction;
Inert atmosphere;
DOI:10.1002/chir.22709
- Guidance literature:
-
1-Bromo-4-fluorobenzene;
With
n-butyllithium;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 1h;
Inert atmosphere;
With
aluminum (III) chloride;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
for 12h;
Inert atmosphere;
1-naphthaldehyde;
enantioselective reaction; Further stages;
DOI:10.1021/jo502070r