Tetraethylene glycol monododecyl ether

Base Information

• Chemical Name: Tetraethylene glycol monododecyl ether
• CAS No.: 5274-68-0
• Molecular Formula: C20H42O5
• Molecular Weight: 362.55
• Hs Code.: 34029000
• European Community (EC) Number: 226-097-1
• NSC Number: 190605
• DSSTox Substance ID: DTXSID3063752
• Nikkaji Number: J151.203J
• Wikidata: Q63395633
• NCI Thesaurus Code: C83866
• RXCUI: 393540
• ChEMBL ID: CHEMBL500128
• Mol file: 5274-68-0.mol

Synonyms:C-12-E-4;C12EO4;dodecyl tetra(oxyethylene) ether;dodecyl-tetraethyleneoxide ether;dodecyltetraethylene glycol monoether;tetraethylene glycol monododecyl ether

Chemical Property of Tetraethylene glycol monododecyl ether

Chemical Property:

• Appearance/Colour: white solid or colourless liquid
• Vapor Pressure: 6.02E-18mmHg at 25°C
• Melting Point: 14°C
• Refractive Index: n20/D 1.453
• Boiling Point: 450.3 °C at 760 mmHg
• PKA: 14.36±0.10(Predicted)
• Flash Point: 226.1 °C
• PSA: 57.15000
• Density: 0.95 g/cm³
• LogP: 3.96600
• Storage Temp.: 2-8°C
• XLogP3: 4.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 22
• Exact Mass: 362.30322444
• Heavy Atom Count: 25
• Complexity: 226

Purity/Quality:

99% ^*data from raw suppliers

Tetraethylene Glycol Monododecyl Ether ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,N
• Statements: 36/37/38-50/53-52/53
• Safety Statements: 26-36-61-60

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Other Uses -> Emulsifiers/Surfactants
• Canonical SMILES: CCCCCCCCCCCCOCCOCCOCCOCCO
• Uses: Tetraethylene Glycol Monododecyl Ether is a well-characterized and non-ionic surfactant.

Technology Process of Tetraethylene glycol monododecyl ether

There total 13 articles about Tetraethylene glycol monododecyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

1-dodecyl alcohol (112-53-8) + 1,3,6,9,12-pentaoxa-2-thiacyclotetradecane 2,2-dioxide → tetraethylene glycol monododecyl ether (5274-68-0,9015-55-8)

Guidance literature:

1-dodecyl alcohol; With sodium hydride; In tetrahydrofuran; mineral oil; for 0.5h; Inert atmosphere;

1,3,6,9,12-pentaoxa-2-thiacyclotetradecane 2,2-dioxide; In tetrahydrofuran; water; mineral oil; pH=2; Inert atmosphere;

With sulfuric acid; In tetrahydrofuran; water; mineral oil; at 80 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.molpharmaceut.7b00496

Reference yield: 57.0%

Tetraethylene glycol (112-60-7) + 1-dodecylbromide (143-15-7) → tetraethylene glycol monododecyl ether (5274-68-0,9015-55-8)

Guidance literature:

With sodium hydride; In dimethyl sulfoxide; at 90 ℃;

DOI:10.1021/js9704036

Reference yield:

oxirane (75-21-8,99932-75-9) + 1-dodecyl alcohol (112-53-8) → tetraethylene glycol monododecyl ether (5274-68-0,9015-55-8)

Guidance literature:

With sodium hydroxide; at 105 ℃; for 4.5h; Inert atmosphere;

upstream raw materials:

oxirane

2-[2-(2-Dodecyloxy-ethoxy)-ethoxy]-ethanol

Tetraethylene glycol

1-dodecylbromide

Downstream raw materials:

heptaethylene glycol monododecyl ether

Octa(ethylene oxide) dodecyl ether

decaethylene glycol monodecyl ether

{2-[2-(2-Dodecyloxy-ethoxy)-ethoxy]-ethoxy}-acetic acid

Refernces

• 1、 -. "Efficient concrete foam stabilizer and preparation method thereof". Paragraph 0027; 0055-0056. . Retrieved 2021/07/17.
• 2、 Karunakaran, Subbaraj,Pandit, Subhendu,Basu, Bikramjit,De, Mrinmoy. "Simultaneous Exfoliation and Functionalization of 2H-MoS2 by Thiolated Surfactants: Applications in Enhanced Antibacterial Activity". . p. 12634 - 12644. Retrieved 2018/10/02.